Not medical advice. Talk to your provider before using any peptide.
Full disclaimerWolverine Peptide Stack — BPC-157, TB-500 & Ipamorelin by Ben Greenfield
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Peptide Schedule Research TeamReviewed Apr 2026
For injury recovery, deep tissue repair, and accelerated healing from training or acute damage.
What This Protocol Does
Five peptides split across three sub-stacks. The healing duo (BPC-157 + TB-500) handles local tissue repair and systemic inflammation. The GH pair (ipamorelin + tesamorelin) triggers bedtime growth hormone release for overnight recovery. GHK-Cu runs as a short burst for collagen remodeling and skin repair. Each sub-stack can run independently; you don't need all five to start.
Who Should Use This
Advanced users who have run at least one peptide cycle before. Budget $400-800 per month for all five peptides. Not recommended for first-timers; start with the 2-peptide Healing Stack (BPC-157 + TB-500) and add the GH pair later if needed. Avoid with active cancer history (BPC-157 and GHK-Cu both promote angiogenesis).
What the Research Says
BPC-157 has over 100 published animal studies on tissue repair, tendon healing, and gut protection (Sikiric et al., PMID 9073154). One human clinical trial tested intra-articular BPC-157 for knee osteoarthritis (Lee and Bhatt, 2021). TB-500 (thymosin beta-4) has Phase 2 data for cardiac repair and wound healing. Ipamorelin and tesamorelin are both clinically studied GH secretagogues; tesamorelin is FDA-approved for HIV lipodystrophy. GHK-Cu has 40+ published studies on wound healing and collagen synthesis.
Important Notices
- Multi-peptide stack — not recommended to start all 5 simultaneously
- GHK-Cu and BPC-157 both promote angiogenesis — avoid with cancer history
- Ipamorelin: avoid food 1 hour before/after injection
Protocol Overview
8 weeks totalTissue Repair Duo
BPC-157 + TB-500
BPC-157 2x/day near injury, TB-500 3x/week abdomen
GH Secretagogue Pair
Ipamorelin + Tesamorelin
Bedtime on empty stomach (90+ min after eating)
Tissue Remodeling
GHK-Cu
Any time, 5-10 day burst only
Supplies Needed
- Insulin syringes (29-31g)
- Bacteriostatic water
- Alcohol swabs
Contraindications
- Active cancer
- Pregnancy or breastfeeding
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
| 350mcg | 2x Daily | subcutaneous (near injury site) | Weeks 1-5 | |
| 3,750mcg | Custom Schedule | subcutaneous (abdomen) | Weeks 1-3 | |
| 300mcg | Custom Schedule | subcutaneous (abdomen) | Weeks 1-12 | |
| 1mg | Custom Schedule | subcutaneous (abdomen) | Weeks 1-8 | |
| 5mg | Daily | subcutaneous | Weeks 1-2 |
BPC-157: 250-350mcg 2x/day or 500-700mcg 1x/day. Also available as 500mcg oral capsule.
TB-500: 2.5-5mg, 2-3x/week. Injection site does not matter — systemic action.
Ipamorelin: 100-500mcg daily, 5 days/week. Same time daily. No food 1hr before/after.
Tesamorelin: 1mg, 1-2x/day, 5 days/week. Before bed 90+ min after eating.
GHK-Cu: 5mg daily for 5-10 days. Also available as transdermal cream.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Koniver's GH Secretagogue Bedtime Stack
BPC-157 + Ipamorelin + Tesamorelin
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.