Not medical advice. Talk to your provider before using any peptide.
Full disclaimerHealing Stack: BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Peptide Schedule Research TeamReviewed Apr 20261 Citation
For accelerated injury recovery using the most popular healing peptide combination.
What This Protocol Does
This stack pairs BPC-157 (local tissue repair) with TB-500 (systemic healing) for a two-pronged recovery approach. BPC-157 upregulates growth factors and promotes angiogenesis at the injury site. TB-500 reduces inflammation and enhances cell migration throughout the body. Community consensus rates this as the gold standard healing combination, with thousands of reports documenting faster recovery from tendon, ligament, muscle, and post-surgical injuries.
Who Should Use This
For beginners through advanced users dealing with moderate to severe injuries, post-surgical recovery, or chronic pain conditions that haven't responded to single-peptide protocols. Requires comfort with subcutaneous injections at two different sites (injury site for BPC-157, any site for TB-500). Avoid if you have active cancer or a history of cancer, as both peptides promote angiogenesis. Not recommended during pregnancy or while taking anticoagulants.
What the Research Says
BPC-157: 100+ preclinical studies demonstrate tendon, ligament, muscle, and GI repair (Sikiric et al., Curr Pharm Des 2011, PMID 21548867). One human trial (Lee 2021) showed knee function improvement. TB-500: Phase I safety data (PMID 34346165) confirmed tolerability. Phase 2 cardiac data showed improved ventricular function. The combination protocol is community-sourced, backed by thousands of user reports on r/Peptides and peptide forums. No clinical trial has tested the BPC-157 + TB-500 combination, but the complementary mechanisms (local vs. systemic) make the pairing logical from a pharmacological standpoint.
Important Notices
- Both peptides promote angiogenesis — contraindicated with active cancer
- Community-sourced protocol — not based on clinical trials
- Neither peptide has FDA approval for this use
Protocol Overview
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
| 250mcg | 2x Daily | subcutaneous (near injury site) | Weeks 1-6 | |
TB-500Loading | 2mg | Custom Schedule | subcutaneous | Weeks 1-4 |
TB-500Maint. | 1mg | Weekly | subcutaneous | Weeks 5-8 |
BPC-157: BPC-157 works locally — inject near injury site when possible.
TB-500: TB-500 is systemic — injection location does not matter.
TB-500: Continue maintenance while BPC-157 cycle completes.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Sources & Citations
- [1]BPC-157 + TB-500 healing stack community protocols — r/Peptides community consensus
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Koniver's GH Secretagogue Bedtime Stack
BPC-157 + Ipamorelin + Tesamorelin
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.