Not medical advice. Talk to your provider before using any peptide.
Full disclaimerBen Greenfield's "Never Get Sick" Immunity Stack
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Peptide Schedule Research TeamReviewed Apr 2026
For long-term immune defense using three peptides that target different layers of the immune system.
What This Protocol Does
TB-500 provides sustained immune modulation over 3-month cycles. Thymalin triggers thymus gland regeneration in short 3-10 day bursts twice a year. LL-37 acts as a direct antimicrobial peptide, killing bacteria and disrupting biofilms during 4-6 week focused cycles.
Who Should Use This
Advanced users with prior peptide experience. Budget $300-600 per month during active cycles. Good for people who get sick frequently or want proactive immune support. Not for anyone on immunosuppressant drugs without physician clearance. Expect Herxheimer reactions from LL-37 if you have SIBO or gut dysbiosis.
What the Research Says
TB-500 (thymosin beta-4) has Phase 2 trial data for wound healing and cardiac repair. LL-37 is a naturally occurring human cathelicidin with published antimicrobial activity against gram-positive and gram-negative bacteria (Vandamme et al., PMID 22000014). Thymalin is a thymic peptide studied in Russian clinical settings for immune reconstitution, with data from Khavinson showing improved T-cell counts in elderly subjects (Khavinson et al., PMID 12602587).
Important Notices
- LL-37: Herxheimer reaction possible (temporary worsening before improvement)
- Each peptide has a different cycle — do not assume same schedule for all
- Consult physician if on immunosuppressants
Protocol Overview
6 weeks totalImmune Support (Long-term)
TB-500
Daily or EOD, 3 months on / 3 months off
Thymus Regeneration (Short Burst)
Thymalin
Daily for 3-10 days, repeat every 6-12 months
Antimicrobial Defense
LL-37
2x/day for 4-6 weeks
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
| 2mg | Every Other Day | subcutaneous | Weeks 1-13 | |
| 100mcg | 2x Daily | subcutaneous | Weeks 1-6 | |
| 7mg | Daily | subcutaneous | Weeks 1-2 |
TB-500: 750mcg-3mg daily or EOD. 3 months on, 3 months off.
LL-37: 100mcg 2x/day for 4-6 weeks. Warning: Herxheimer reaction possible.
Thymalin: 5-10mg daily for 3-10 days. Repeat every 6-12 months.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Dr. Koniver's GH Secretagogue Bedtime Stack
BPC-157 + Ipamorelin + Tesamorelin
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.