What is the recommended Thymalin dosage?

Thymalin dosing varies by experience level. Beginners typically start at 5000mcg daily, moderate users at 10000mcg daily, and aggressive protocols use 20000mcg daily.

How do you reconstitute Thymalin?

Thymalin typically comes in 10mg vials. Add 2mL of bacteriostatic water to the vial. Use our free calculator for exact syringe units based on your desired dose.

What is the half-life of Thymalin?

The half-life of Thymalin is ~2-4 hours (estimated). This determines how frequently you need to dose for consistent blood levels.

Thymalin

ImmuneInjectionResearchGrade B~2-4 hours (estimated) half-life

Thymic BioregulatorImmune RestorationAnti-AgingT-Cell Modulation1 weeks on / 25 weeks off

Benefits

Restores T-cell counts and CD4/CD8 balance

Enhances natural killer cell activity

Reduces infection frequency in elderly populations

Short treatment courses (5-10 days) with lasting effects

Over 40 years of clinical use with strong safety record

Associated with reduced mortality in long-term geroprotective studies

Half-Life

~2-4 hours

Route

Injection

Frequency

Daily

Vial Sizes

10mg

BAC Water

2mL

Safety Grade

Grade B

Open Thymalin Dosage Calculator

Calculate exact syringe units for your vial and dose

About Thymalin

Thymalin is a natural peptide complex isolated from calf thymus gland, developed by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It contains several bioactive short peptides — most notably the dipeptide L-Glu-L-Trp (EW), which was later synthesized as the drug Thymogen. Thymalin activates T-cell differentiation, restores CD4/CD8 ratios, enhances natural killer cell activity, and modulates cytokine production. It has been used in Russian and Eastern European clinical practice for over 40 years as an immunocorrector, particularly in elderly patients with age-related immune decline.

Who Should Consider Thymalin

Adults over 60 with age-related immune decline (immunosenescence)
Individuals with chronic or recurrent infections
Post-surgical or post-illness immune recovery
Those seeking periodic immune system maintenance
Patients with reduced T-cell counts or impaired CD4/CD8 ratios

How Thymalin Works

Thymalin contains short peptides (EW, KE, EDP) that bind to double-stranded DNA and histone proteins, regulating expression of genes involved in immune function. The primary dipeptide L-Glu-L-Trp activates T-cell differentiation, enhances T-cell recognition of peptide-MHC complexes, modulates intracellular cyclic nucleotide levels, and stimulates neutrophil chemotaxis and phagocytosis. It also promotes hematopoietic stem cell differentiation into mature immune cells and regulates cytokine production (IL-2, IFN) to restore balanced immune responses.

What to Expect

Days 1-3

Treatment initiation. No noticeable changes yet. Peptide begins modulating gene expression in immune cells and thymic tissue.

Days 4-7

Early immune markers begin shifting. Some patients report improved energy or reduced frequency of minor symptoms. T-cell precursor differentiation accelerates.

Days 8-10

Course completion. Measurable improvements in T-cell counts and CD4/CD8 ratios in clinical studies. NK cell activity increases.

Weeks 2-8

post-course

Immune improvements continue to develop after the course ends. Reduced incidence of acute respiratory infections observed in clinical cohorts. Immune markers stabilize at improved levels.

Months 3-6

maintenance

Sustained immune benefits from a single course. Khavinson studies showed reduced infection rates and improved survival persisting for 6+ months. Next course typically administered at the 6-month mark.

Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	5mg	Daily
Moderate	10mg	Daily
Aggressive	20mg	Daily

Note: Thymic peptide bioregulator developed by Khavinson. Standard protocol is 5-10mg daily for 5-10 days, repeated every 6 months. Contains active dipeptides EW (Glu-Trp) and KE. Extracted from calf thymus.

How to Inject Thymalin

Dissolve lyophilized powder in 1-2 mL bacteriostatic water or sterile saline. Inject intramuscularly (preferred in clinical protocols) or subcutaneously once daily. Administer at the same time each day for the full 5-10 day course. Rotate injection sites.

Cycling Protocol

On Period

1 weeks

Off Period

25 weeks

Bioregulator protocol: 5-10 day course repeated every 6 months. Effects persist well beyond the treatment window. Some protocols call for annual courses in younger adults and biannual courses in those over 60.

Pharmacokinetics

Half-Life

Bioavailability

IM/SC: not formally characterized

Tmax

~30-60 minutes (estimated)

Data Confidence

low

Source: Estimated from dipeptide/short peptide pharmacokinetics; no formal PK study published for Thymalin complex

Pharmacokinetics — Active Dose Over Time

Loading the interactive decay curve.

Side Effects

Very well-tolerated across decades of clinical use. Practically non-toxic. Rare mild injection site reactions. Transient low-grade fever reported infrequently.

Contraindications

Pregnancy or breastfeeding
Known hypersensitivity to thymic peptides or bovine-derived products
Active autoimmune conditions requiring immunosuppressive therapy
Organ transplant recipients on anti-rejection medications
Severe allergic reactions to animal-derived biological products

Drug Interactions

Immunosuppressants (tacrolimus, cyclosporine, mycophenolate) — Thymalin may counteract immunosuppressive effects
Other thymic peptides (Thymosin Alpha 1, Thymogen, T-activin) — overlapping mechanisms; avoid concurrent use without medical guidance
Corticosteroids — high-dose steroids may blunt immunostimulatory effects of Thymalin
Vaccines — timing may need adjustment; Thymalin could alter immune response to vaccination