LL-37 Dosage Calculator

Reconstitution math for a 5 mg vial with 2 mL bacteriostatic water: total volume is 200 units on an insulin syringe. Each unit delivers 25 mcg. So 50 mcg is 2 units, 100 mcg is 4 units, 125 mcg is 5 units, 200 mcg is 8 units. Start at 50 mcg daily (2 units) for the first week regardless of experience level. LL-37 is potent enough that skipping the titration week creates unnecessary risk. The dosing frequency listed in most structured references is 2 to 3 times per week. Community consensus and pharmacological logic both point to daily dosing. With a systemic half-life under 30 minutes, twice-weekly injections leave zero circulating peptide between doses. Source matters more with LL-37 than many peptides. Request HPLC purity certificates showing 98% or higher and mass spectrometry confirmation of the correct molecular weight (4493.3 Da). Endotoxin (LAL) test certificates are non-negotiable for any antimicrobial peptide. Verify the vendor uses solid-phase peptide synthesis, not E. coli expression systems that carry LPS contamination risk. Reconstituted vials go in the refrigerator at 2 to 8 degrees Celsius. Use within 4 weeks. Discard if you see particles, cloudiness, or color change.