Not medical advice. Talk to your provider before using any peptide.
Full disclaimerDr. Holtorf's Immune Modulation Protocol
Three peptides for immune modulation, gut healing, and telomere maintenance. TA-1 at clinical dose (1.6mg 2x/week), oral BPC-157 for gut health, and Epithalon in 10-day pulses. Note: Holtorf co-founded Integrative Peptides which sells oral BPC-157.
Peptide Schedule Research TeamReviewed Apr 2026
For immune modulation, gut healing, and telomere maintenance using three peptides at clinical doses.
What This Protocol Does
TA-1 at 1.6mg twice weekly provides ongoing immune modulation through T-cell activation. Oral BPC-157 at 500mcg daily targets GI healing directly through the gut lining. Epithalon runs as a 10-day pulse every 6 months for telomerase activation and telomere maintenance. Each sub-stack is standalone and targets a different system. The oral BPC-157 route is unusual; most protocols use subcutaneous injection.
Who Should Use This
Intermediate users looking for immune support, gut healing, or longevity in a simpler package than a 4-5 peptide stack. Disclosure: Holtorf co-founded Integrative Peptides LLC, which sells oral BPC-157. The FTC issued a warning letter for unsubstantiated claims. Evaluate the protocol on its merits, but factor in the commercial interest. Budget is moderate since TA-1 and oral BPC-157 run long-term while epithalon is only pulsed twice per year.
What the Research Says
Thymosin alpha-1 is approved in 30+ countries and has clinical trial data showing improved T-cell counts, NK cell activity, and dendritic cell maturation (Tuthill et al., PMID 10813511). The standard clinical dose (1.6mg) matches the Zadaxin label used in hepatitis trials. BPC-157 has 100+ preclinical studies on tissue repair and gut protection (Sikiric et al., PMID 9073154). Oral bioavailability data for BPC-157 is limited; most published studies used injection. Epithalon follows the Khavinson protocol for telomerase activation (Khavinson, PMID 14523363). No studies test this 3-peptide combination together.
Important Notices
- Commercial conflict: Holtorf co-founded Integrative Peptides LLC
- FTC warning letter for unsubstantiated claims
- RAADFest 2024 safety incident
Protocol Overview
Immune Modulation
Thymosin Alpha 1
2x/week ongoing
Gut Health
BPC-157
Daily oral capsule
Anti-Aging
Epithalon
10-day pulse every 6 months
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
Thymosin Alpha 1Maint. | 1.6mg | Custom Schedule | subcutaneous | Week 1+ |
BPC-157Maint. | 500mcg | Daily | oral | Week 1+ |
| 10mg | Daily | subcutaneous | Weeks 1-2 |
Thymosin Alpha 1: 1.6mg 2x/week. "Approved in over 30 countries."
BPC-157: 500mcg oral capsule daily for GI healing.
Epithalon: 10mg daily for 10 days. Repeat every 6 months.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Koniver's GH Secretagogue Bedtime Stack
BPC-157 + Ipamorelin + Tesamorelin
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.