Not medical advice. Talk to your provider before using any peptide.
Full disclaimerDr. Koniver's GH Secretagogue Bedtime Stack
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Peptide Schedule Research TeamReviewed Apr 2026
For bedtime growth hormone optimization and tissue healing in a single combined injection.
What This Protocol Does
Three peptides drawn into one syringe and injected subcutaneously at bedtime. Ipamorelin and tesamorelin trigger a natural GH pulse during sleep. BPC-157 runs alongside for tissue repair and gut healing. The 5-on-2-off schedule prevents receptor desensitization while keeping the protocol simple.
Who Should Use This
Intermediate users comfortable with reconstitution and drawing multiple peptides into one syringe. Budget $200-400 per month. Requires IGF-1, fasting glucose, and HbA1c bloodwork before starting and every 12 weeks. Not for anyone with active cancer, elevated IGF-1, or insulin resistance without physician oversight.
What the Research Says
Ipamorelin is a selective GH secretagogue with clinical trial data showing dose-dependent GH release without significant cortisol or prolactin elevation (Raun et al., PMID 9849822). Tesamorelin is FDA-approved for HIV-associated lipodystrophy (Falutz et al., PMID 17911399) and shown to reduce visceral adipose tissue by 15-18% in clinical trials. BPC-157 has 100+ preclinical studies on tissue repair (Sikiric et al., PMID 9073154). Dr. Koniver confirmed this exact combination on Huberman Lab Ep 197.
Important Notices
- No food 45 minutes before injection (insulin blunts GH release)
- Tesamorelin is FDA-approved for visceral fat but off-label in this combo
- Monitor IGF-1 levels periodically
Protocol Overview
12 weeks totalBedtime GH + Healing Stack
BPC-157 + Ipamorelin + Tesamorelin
Bedtime, empty stomach (no food 45 min before)
Recommended Labwork
- IGF-1 levels
- Fasting glucose
- HbA1c
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
BPC-157Maint. | 500mcg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
IpamorelinMaint. | 100mcg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
TesamorelinMaint. | 2mg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
BPC-157: 500mcg at bedtime, 5on/2off. Combined in single syringe with ipamorelin + tesamorelin.
Ipamorelin: 100mcg max at bedtime. No food 45 min before. 5on/2off.
Tesamorelin: 2mg at bedtime. FDA-approved for visceral fat. 5on/2off.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.