Dr. Koniver's GH Secretagogue Bedtime Stack
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Peptide Schedule Research TeamReviewed Apr 2026
For bedtime growth hormone optimization and tissue healing in a single combined injection.
What This Protocol Does
Three peptides drawn into one syringe and injected subcutaneously at bedtime. Ipamorelin and tesamorelin trigger a natural GH pulse during sleep. BPC-157 runs alongside for tissue repair and gut healing. The 5-on-2-off schedule prevents receptor desensitization while keeping the protocol simple.
Who Should Use This
Intermediate users comfortable with reconstitution and drawing multiple peptides into one syringe. Budget $200-400 per month. Requires IGF-1, fasting glucose, and HbA1c bloodwork before starting and every 12 weeks. Not for anyone with active cancer, elevated IGF-1, or insulin resistance without physician oversight.
What the Research Says
Ipamorelin is a selective GH secretagogue with clinical trial data showing dose-dependent GH release without significant cortisol or prolactin elevation (Raun et al., PMID 9849822). Tesamorelin is FDA-approved for HIV-associated lipodystrophy (Falutz et al., PMID 17911399) and shown to reduce visceral adipose tissue by 15-18% in clinical trials. BPC-157 has 100+ preclinical studies on tissue repair (Sikiric et al., PMID 9073154). Dr. Koniver confirmed this exact combination on Huberman Lab Ep 197.
Important Notices
- No food 45 minutes before injection (insulin blunts GH release)
- Tesamorelin is FDA-approved for visceral fat but off-label in this combo
- Monitor IGF-1 levels periodically
Protocol Overview
12 weeks totalBedtime GH + Healing Stack
BPC-157 + Ipamorelin + Tesamorelin
Bedtime, empty stomach (no food 45 min before)
Recommended Labwork
- IGF-1 levels
- Fasting glucose
- HbA1c
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
BPC-157Maint. | 500mcg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
IpamorelinMaint. | 100mcg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
TesamorelinMaint. | 2mg | Custom Schedule | subcutaneous (abdomen) | Week 1+ |
BPC-157: 500mcg at bedtime, 5on/2off. Combined in single syringe with ipamorelin + tesamorelin.
Ipamorelin: 100mcg max at bedtime. No food 45 min before. 5on/2off.
Tesamorelin: 2mg at bedtime. FDA-approved for visceral fat. 5on/2off.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
BPC-157 Conservative Healing Protocol
BPC-157
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.