Not medical advice. Talk to your provider before using any peptide.
Full disclaimerBPC-157 Conservative Healing Protocol
Conservative 6-week healing protocol using beginner-tier dosing. Inject near injury site for local repair or abdomen for systemic/gut effects.
Peptide Schedule Research TeamReviewed Apr 20262 Citations
For targeted tissue repair, injury recovery, and gut healing.
What This Protocol Does
BPC-157 is a 15-amino-acid peptide derived from human gastric juice that accelerates wound healing, tendon repair, and gut mucosal recovery in animal models. It upregulates growth factor expression (VEGF, EGF) and promotes angiogenesis at injury sites. Over 100 preclinical studies show consistent tissue repair effects across tendons, ligaments, muscle, bone, and GI tissue.
Who Should Use This
Suitable for beginners with acute soft tissue injuries (tendons, ligaments, muscle strains) or chronic gut issues. No prior peptide experience needed. Inject subcutaneously near the injury site for local effects, or in the abdomen for systemic and gut healing. Avoid if you have active cancer or a history of cancer (BPC-157 promotes angiogenesis). Not recommended during pregnancy or breastfeeding.
What the Research Says
BPC-157: Over 100 animal studies demonstrate tissue repair across tendons (Staresinic et al., J Orthop Res 2003, PMID 12706025), ligaments, muscle, and GI mucosa. Sikiric et al. (Curr Pharm Des 2011, PMID 21548867) reviewed GI tract healing mechanisms. One human trial exists: Lee et al. (2021) showed improved knee function scores in osteoarthritis patients. Pharmacokinetic data (He et al., Front Pharmacol 2022, PMID 36588717) confirmed safety and distribution in rats and dogs. All dosing is extrapolated from animal data and community use patterns.
Important Notices
- No human clinical trials — all dosing is extrapolated from animal studies and community use
- Promotes angiogenesis — avoid if history of cancer
- Not recommended during pregnancy or breastfeeding
Protocol Overview
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
| 250mcg | 2x Daily | subcutaneous (near injury site) | Weeks 1-6 |
BPC-157: Inject as close to injury site as possible. For gut healing, use oral or abdominal SC.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Sources & Citations
Peptide Profiles & Calculators
Related Healing & Recovery Protocols
TB-500 Loading + Maintenance Protocol
TB-500
Standard loading + maintenance cycle: 4 weeks at full dose (2x/week), then 4 weeks maintenance at half dose (1x/week). Systemic — injection site does not matter.
Healing Stack: BPC-157 + TB-500
BPC-157 + TB-500
Gold-standard healing combination. BPC-157 for local tissue repair + TB-500 for systemic healing. 6-week protocol with TB-500 loading then maintenance.
Wolverine Stack
BPC-157 + TB-500 + Ipamorelin +2
Five peptides, three sub-stacks, and a torn hamstring that started it all. Ben Greenfield published full dosing for BPC-157, TB-500, ipamorelin, tesamorelin, and GHK-Cu after using the combo to recover from a persistent upper leg injury. The healing duo (BPC-157 + TB-500) can be run alone; the GH pair (ipamorelin + tesamorelin) adds recovery optimization at bedtime. Budget $400-800/month and plan for 4-12 weeks on, equal time off.
Never Get Sick Stack
TB-500 + Thymalin + LL-37
Three peptides, three different cycle lengths, one goal: stop getting sick. Greenfield pairs TB-500 (3 months on, 3 off) with Thymalin (3-10 day bursts every 6-12 months) and LL-37 (4-6 week antimicrobial cycles). Each targets a different layer of immune defense. Warning on LL-37: Herxheimer reactions are common in the first two weeks if you have SIBO or gut dysbiosis.
Dr. Koniver's GH Secretagogue Bedtime Stack
BPC-157 + Ipamorelin + Tesamorelin
One syringe, three peptides, taken at bedtime. Dr. Koniver confirmed on Huberman Lab Ep 197 that he combines BPC-157 (500mcg), ipamorelin (100mcg), and tesamorelin (2mg) in a single subcutaneous injection. Schedule is 5 days on, 2 off. No food for 45 minutes before. The single-syringe detail settled a long-running debate about whether these peptides could be mixed safely.
Dr. Edwin Lee's BPC-157 Knee Protocol (Clinical Trial)
BPC-157
The only peer-reviewed human BPC-157 clinical trial, published in Alternative Therapies (2021). Dr. Edwin Lee injected 4mg BPC-157 directly into knee joints. Seven out of 12 patients reported pain relief lasting 6+ months from a single injection. The route is intra-articular, not subcutaneous. This is a physician-administered procedure, not a self-injection protocol.