Not medical advice. Talk to your provider before using any peptide.
Full disclaimerBryan Johnson's Thymus Rejuvenation Protocol
Bryan Johnson's thymus rejuvenation protocol from Project Blueprint. Epithalon (10mg/day) and Thymosin Alpha-1 (1.5mg/day) injected IM for 5 consecutive days, then nothing for 6 months. Follows the Khavinson protocol. Dosing sourced from tweets; the original post had ambiguous wording that the community later resolved. Budget $100-250 per pulse cycle.
Peptide Schedule Research TeamReviewed Apr 2026
For thymus regeneration and immune rejuvenation using short 5-day peptide pulses twice per year.
What This Protocol Does
Epithalon (10mg/day) and thymosin alpha-1 (1.5mg/day) injected intramuscularly for 5 consecutive days, then nothing for 6 months. Epithalon targets telomere maintenance through telomerase activation. TA-1 stimulates T-cell production and thymus function. The pulse-and-wait approach follows the Khavinson protocol used in Russian longevity research for decades.
Who Should Use This
Advanced users interested in longevity and immune optimization. Budget $100-250 per pulse cycle (2 cycles per year). Requires comfort with intramuscular injections. Not for beginners; start with subcutaneous protocols first. Get complete blood count and thymus function markers before starting. Dosing was sourced from tweets, so verify with a physician.
What the Research Says
Epithalon (epitalon) is based on the work of Dr. Vladimir Khavinson, who published studies showing telomerase activation and improved survival in elderly patients (Khavinson, PMID 14523363). The standard Khavinson protocol uses 5-10mg daily for 5-10 days, repeated every 4-6 months. Thymosin alpha-1 is FDA-approved in over 30 countries for hepatitis B and C. Clinical trials show it enhances T-cell function, NK cell activity, and dendritic cell maturation (Tuthill et al., PMID 10813511).
Important Notices
- Intramuscular injection — requires proper technique
- Dosing sourced from tweets — verify with physician
- Khavinson protocol — well-established but limited Western clinical data
Protocol Overview
1 weeks totalThymus Rejuvenation Pulse
Epithalon + Thymosin Alpha 1
5 consecutive days of IM injections, every 6 months
Recommended Labwork
- Complete blood count
- Thymus function markers
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
| 10mg | Daily | subcutaneous | Week 1 | |
| 1,500mcg | Daily | subcutaneous | Week 1 |
Epithalon: 10mg/day IM for 5 consecutive days. Khavinson protocol. Repeat every 6 months.
Thymosin Alpha 1: 1.5mg/day for 5 consecutive days. Run concurrently with epithalon.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
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