Dr. Edwin Lee's Longevity Protocol
Peptide Schedule Research TeamReviewed Apr 2026
Epithalon at 5mg daily for 10 days (2x/year) as his "#1 longevity peptide," plus TA-1 at a lower-than-standard 250mcg maintenance dose (1-2x/week, daily when sick). Discussed on the Dr. Hyman Show podcast.
Protocol Source
Important Notices
- ⚠TA-1 dose (250mcg) is lower than standard clinical dosing (1.5-1.6mg)
Sub-Stacks
This protocol contains 2 groups. Each can be started independently unless noted.
Telomere Maintenance
Epithalon pulse for telomerase activation
Timing: 10-day pulse, 2x/year
Immune Support
Low-dose TA-1 maintenance
Timing: 1-2x/week, daily when sick
Protocol Phases
5mg daily for 10 days, 2x/year. "#1 longevity peptide."
250mcg 1-2x/week maintenance. 1mg daily when sick. Lower than standard (1.5mg).
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Use This ProtocolRelated Protocols
Bryan Johnson's Thymus Rejuvenation Protocol
Bryan Johnson's thymus rejuvenation protocol from Project Blueprint. Epithalon (10mg/day) and Thymosin Alpha-1 (1.5mg/day) injected IM for 5 consecutive days, then nothing for 6 months. Follows the Khavinson protocol. Dosing sourced from tweets; the original post had ambiguous wording that the community later resolved. Budget $100-250 per pulse cycle.
via Bryan JohnsonBen Pakulski's 30-Day Longevity Stack
Four peptides, four aging mechanisms, 30 days. Ben Pakulski targets mitochondria with SS-31 (10mg daily), telomeres with Epithalon (5mg, 5x/week), immune function with TA-1 (1.5mg daily), and senescent cells with FOXO4-DRI (10mg EOD for 2 weeks). The FOXO4-DRI dose is 3.3x the standard aggressive tier. Budget $500-1,200 and consider starting with 1-2 peptides rather than all four simultaneously.
via Ben PakulskiJF Tremblay's Anti-Aging Stack
A biochemist's anti-aging approach: Epithalon at ~3.3-5mg/day for 20-30 days (100mg total per cycle, 2-3x/year) plus BPC-157 in two modes: 10mg monthly high-dose pulse or 250mcg daily for 2 weeks on / 6 weeks off. Tremblay owns CanLab and has 30+ years in peptide manufacturing.
Not medical advice. Talk to your provider before using any peptide.
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