Not medical advice. Talk to your provider before using any peptide.
Full disclaimerHuberman Sermorelin Protocol (DISCONTINUED)
Two years on sermorelin for deep sleep, then he stopped. Huberman tracked everything with Eight Sleep and WHOOP; the data showed REM sleep depletion and elevated PSA (prostate-specific antigen). He disclosed this on Ep 170 as cautionary data. Dose is a discussed range, not his exact personal dose. This protocol is discontinued, but the discontinuation data is what makes it worth studying.
Peptide Schedule Research TeamReviewed Apr 2026
A discontinued GH secretagogue protocol, documented here for the cautionary sleep and PSA data Huberman disclosed.
What This Protocol Does
Sermorelin at 200-400mcg injected subcutaneously before sleep, 5 days on, 2 off. Huberman ran this for two years to improve deep sleep. He tracked sleep architecture with Eight Sleep and WHOOP. The protocol increased deep sleep initially but depleted REM sleep over time and raised PSA (prostate-specific antigen). He stopped and disclosed the negative data on Ep 170.
Who Should Use This
This protocol is discontinued. It's documented here because Huberman's discontinuation data is unusually detailed. If you're considering sermorelin, review this data first. Monitor PSA and sleep architecture with a wearable if you proceed. Not recommended without physician oversight and baseline PSA testing. The dose is a discussed range, not Huberman's confirmed personal dose.
What the Research Says
Sermorelin is an FDA-approved GHRH analog (approved in 1997 for pediatric GH deficiency, later withdrawn from market in 2008). Clinical data confirmed it stimulates endogenous GH release (Walker et al., PMID 2040896). No published clinical trials tested sermorelin specifically for sleep improvement. Huberman's PSA elevation is consistent with known effects of sustained GH elevation on prostate tissue, flagged in GH therapy literature (Colao et al., PMID 10463529). Community reports on sermorelin for sleep are mixed, with some users reporting similar REM depletion patterns.
Important Notices
- DISCONTINUED by Huberman — suppressed REM sleep, spiked PSA
- Dose is a discussed range, not exact personal dose
- Monitor PSA and sleep architecture if using sermorelin
Protocol Overview
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
SermorelinMaint. | 300mcg | Custom Schedule | subcutaneous | Week 1+ |
Sermorelin: 200-400mcg pre-sleep. DISCONTINUED: nuked REM sleep, spiked PSA. Discussed range, not exact personal dose.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
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