Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20266 Citations
Sermorelin29 residuesYADAIFTNSYRKVLGQLSARKLLQDIMSREach bubble = one amino acid. Size = residue mass. Color = chemical class.Sermorelin is the original GHRH analog with the longest clinical track record of any GH peptide. FDA-approved then voluntarily discontinued for non-safety reasons. Decades of data, conservative dosing, and a predictable side-effect profile make it the default beginner choice for GH optimization.
200mcg · Daily
Summary: Add 2mL BAC water to your 5mg vial. Draw to 8.0 units on a U-100 syringe for a 200mcg dose. This vial will last 25 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 200mcg | Daily |
| Moderate | 300mcg | Daily |
| Aggressive | 500mcg | Daily |
With a 5 mg vial and 2 mL bacteriostatic water, you get 2,500 mcg/mL. At that concentration: 200 mcg is 8 units on a U-100 insulin syringe, 300 mcg is 12 units, and 500 mcg is 20 units. The fasting window is where most beginners fail. You need at least two hours with no food before the injection. Insulin triggers somatostatin release from the hypothalamus, which directly opposes GH secretion. Eating within that window doesn't just reduce the effect; it negates it. Bedtime dosing is the priority. Sermorelin amplifies the natural nocturnal GH pulse during slow-wave sleep. Inject 30 to 60 minutes before sleep for best results. Store reconstituted vials at 2 to 8 degrees Celsius. Discard anything cloudy or with visible particles. Lyophilized powder is more stable but still belongs in the fridge. If you see no sleep improvement after two weeks with correct timing, check your reconstitution math first. Then get an IGF-1 draw at week six. If IGF-1 isn't moving, suspect the product quality before blaming the peptide. Most users stack sermorelin with ipamorelin. The two hit different receptor pathways (GHRH-R and GHS-R1a) and produce a synergistic GH pulse larger than either alone.
Dosing based on Compounded sermorelin: community dosing consensus — 10 published references.View all sources →
Cross-check your Sermorelin reconstitution math with AI
Neuroscientist & Stanford Professor
I stopped taking it because REM depletion was something I didn't want.
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Sermorelin is the original GHRH analog with the longest clinical track record of any GH peptide. FDA-approved then voluntarily discontinued for non-safety reasons. Decades of data, conservative dosing, and a predictable side-effect profile make it the default beginner choice for GH optimization.
