Bryan Johnson's Tirzepatide Microdose (DISCONTINUED)
Peptide Schedule Research TeamReviewed Apr 2026
Three weeks, then done. Johnson tried tirzepatide at 0.5mg weekly (1/5th the standard starting dose) and halted when his data turned negative: resting heart rate up 3bpm, HRV down 7 points, sleep quality down 10%. He already had optimal metabolic markers, so the risk outweighed any benefit. This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached.
Protocol Source
Important Notices
- ⚠DISCONTINUED after 3 weeks due to adverse biomarker changes
- ⚠Even at 1/5th standard dose, measurable negative effects on cardiovascular and sleep metrics
- ⚠Johnson already had optimal metabolic markers — risk outweighed benefit
Protocol Phases
0.5mg weekly. DISCONTINUED after 3 weeks: +3bpm RHR, -7pts HRV, -10% sleep quality.
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