Peter Attia's GLP-1 Clinical Perspective
Peptide Schedule Research TeamReviewed Apr 2026
Peter Attia prescribes GLP-1 agonists clinically and flagged the lean mass loss problem early: 39% of weight lost in the STEP 1 trial was lean tissue. His protocol follows standard FDA titration (0.25mg to 1mg+ weekly) but pairs it with resistance training and 1g protein per pound of bodyweight. This is a prescriber's perspective, not personal biohacking. DEXA scans and metabolic panels required.
Protocol Source
Important Notices
- ⚠Prescriber perspective — Attia prescribes these, not personal biohacking
- ⚠39% of weight loss in STEP 1 trial was lean mass — resistance training is essential
- ⚠GI side effects common during titration
- ⚠Do not combine with other GLP-1 agonists
Recommended Labwork
- HbA1c
- Lipid panel
- Body composition (DEXA)
- Metabolic panel
Recommended Supplements
- Whey protein · 1g/lb bodyweight daily — Counteract lean mass loss
- Creatine · 5g daily — Support muscle retention
Protocol Phases
Standard FDA titration. Attia emphasizes resistance training + 1g/lb protein alongside.
Increase to 0.5mg weekly. Monitor GI side effects.
Maintenance at 1mg weekly. Attia notes 39% lean mass loss concern.
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