Not medical advice. Talk to your provider before using any peptide.
Full disclaimerTirzepatide Titration Protocol (Mounjaro/Zepbound)
FDA-standard weekly titration from 2.5mg to 15mg. Many maintain at 7.5-10mg without reaching max dose.
Peptide Schedule Research TeamReviewed Apr 20261 Citation
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Important Notices
- Do not use with other GLP-1 or GIP receptor agonists
- Risk of thyroid C-cell tumors — same class warning as semaglutide
- GI side effects common during titration (nausea, diarrhea)
Protocol Phases
Goal isn't always max dose — many maintain at 7.5-10mg
Metrics Tracked
Sources & Citations
Schedule This Protocol
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Related Weight Loss Protocols
Semaglutide Titration Protocol (Ozempic/Wegovy)
Semaglutide
FDA-standard weekly titration from 0.25mg to 2.4mg over 16+ weeks. Hold current dose for an extra 4 weeks if GI side effects are severe.
Retatrutide Titration Protocol (Triple G)
Retatrutide
Phase 3 trial protocol: weekly titration from 1mg to 12mg. Triple GLP-1/GIP/Glucagon agonist with up to 24% weight loss in clinical trials.
Semaglutide Microdose
Semaglutide
Semaglutide at 0.025-0.05mg weekly, roughly 1/10th the standard starting dose. Dr. Tyna Moore's philosophy: "Dose up to appetite control, not suppression." Exact microgram dose is not publicly verified; the approach and philosophy come from multiple interviews including Ben Greenfield Life. She treats GLP-1 as scaffolding for building metabolic habits, not a permanent prescription.
Peter Attia's GLP-1 Clinical Perspective
Semaglutide + Tirzepatide
Peter Attia prescribes GLP-1 agonists clinically and flagged the lean mass loss problem early: 39% of weight lost in the STEP 1 trial was lean tissue. His protocol follows standard FDA titration (0.25mg to 1mg+ weekly) but pairs it with resistance training and 1g protein per pound of bodyweight. This is a prescriber's perspective, not personal biohacking. DEXA scans and metabolic panels required.
Bryan Johnson's Tirzepatide Microdose (DISCONTINUED)
Tirzepatide
Three weeks, then done. Johnson tried tirzepatide at 0.5mg weekly (1/5th the standard starting dose) and halted when his data turned negative: resting heart rate up 3bpm, HRV down 7 points, sleep quality down 10%. He already had optimal metabolic markers, so the risk outweighed any benefit. This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached.