Not medical advice. Talk to your provider before using any peptide.
Full disclaimerSemaglutide Microdosing Protocol — 1/10th Dose by Dr. Tyna Moore
Semaglutide at 0.025-0.05mg weekly, roughly 1/10th the standard starting dose. Dr. Tyna Moore's philosophy: "Dose up to appetite control, not suppression." Exact microgram dose is not publicly verified; the approach and philosophy come from multiple interviews including Ben Greenfield Life. She treats GLP-1 as scaffolding for building metabolic habits, not a permanent prescription.
Peptide Schedule Research TeamReviewed Apr 2026
For gentle weight management using semaglutide at 1/10th the standard starting dose to minimize side effects.
What This Protocol Does
Semaglutide at 0.025-0.05mg weekly (25-50mcg), roughly 1/10th the standard 0.25mg starting dose. The goal is appetite control without appetite suppression. Dr. Tyna Moore treats GLP-1 agonists as temporary scaffolding for building metabolic habits, not as a permanent prescription. You titrate up only to the point where cravings decrease, then hold.
Who Should Use This
Beginners or anyone concerned about GLP-1 side effects (nausea, gastroparesis, muscle loss). Budget $30-80 per month at microdose levels. Good for people who want metabolic support while building exercise and nutrition habits. Not for anyone seeking rapid weight loss; standard semaglutide dosing is 5-10x higher. Consult a physician before starting any GLP-1 protocol.
What the Research Says
Semaglutide has extensive clinical trial data at standard doses. The STEP 1 trial (PMID 33567185) showed 14.9% body weight reduction at 2.4mg weekly. No published clinical trials exist at the microdose range (0.025-0.05mg). The microdosing approach is based on Dr. Moore's clinical experience with patients who had poor GI tolerance at standard doses. Community reports suggest fewer side effects but slower weight loss at this range.
Important Notices
- Sub-therapeutic by standard definitions — less clinical evidence at this dose range
- Exact microgram dose not publicly verified
- Standard semaglutide titration starts at 0.25mg (10x this approach)
- Consult physician before starting any GLP-1 protocol
Protocol Overview
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
SemaglutideMaint. | 37mcg | Weekly | subcutaneous (abdomen) | Week 1+ |
Semaglutide: 0.025-0.05mg weekly (25-50mcg). 1/10th standard dose. Exact mcg not publicly verified.
Metrics Tracked
Schedule This Protocol
Set your start date and track every dose in your calendar.
Peptide Profiles & Calculators
Related Weight Loss Protocols
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Tirzepatide Titration Protocol (Mounjaro/Zepbound)
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Retatrutide Titration Protocol (Triple G)
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Peter Attia's GLP-1 Clinical Perspective
Semaglutide + Tirzepatide
Peter Attia prescribes GLP-1 agonists clinically and flagged the lean mass loss problem early: 39% of weight lost in the STEP 1 trial was lean tissue. His protocol follows standard FDA titration (0.25mg to 1mg+ weekly) but pairs it with resistance training and 1g protein per pound of bodyweight. This is a prescriber's perspective, not personal biohacking. DEXA scans and metabolic panels required.
Bryan Johnson's Tirzepatide Microdose (DISCONTINUED)
Tirzepatide
Three weeks, then done. Johnson tried tirzepatide at 0.5mg weekly (1/5th the standard starting dose) and halted when his data turned negative: resting heart rate up 3bpm, HRV down 7 points, sleep quality down 10%. He already had optimal metabolic markers, so the risk outweighed any benefit. This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached.