Dr. Tyna Moore's Semaglutide Microdosing Protocol
Peptide Schedule Research TeamReviewed Apr 2026
Semaglutide at 0.025-0.05mg weekly, roughly 1/10th the standard starting dose. Dr. Tyna Moore's philosophy: "Dose up to appetite control, not suppression." Exact microgram dose is not publicly verified; the approach and philosophy come from multiple interviews including Ben Greenfield Life. She treats GLP-1 as scaffolding for building metabolic habits, not a permanent prescription.
Protocol Source
Important Notices
- ⚠Sub-therapeutic by standard definitions — less clinical evidence at this dose range
- ⚠Exact microgram dose not publicly verified
- ⚠Standard semaglutide titration starts at 0.25mg (10x this approach)
- ⚠Consult physician before starting any GLP-1 protocol
Protocol Phases
0.025-0.05mg weekly (25-50mcg). 1/10th standard dose. Exact mcg not publicly verified.
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Peter Attia's GLP-1 Clinical Perspective
Peter Attia prescribes GLP-1 agonists clinically and flagged the lean mass loss problem early: 39% of weight lost in the STEP 1 trial was lean tissue. His protocol follows standard FDA titration (0.25mg to 1mg+ weekly) but pairs it with resistance training and 1g protein per pound of bodyweight. This is a prescriber's perspective, not personal biohacking. DEXA scans and metabolic panels required.
via Peter AttiaBryan Johnson's Tirzepatide Microdose (DISCONTINUED)
Three weeks, then done. Johnson tried tirzepatide at 0.5mg weekly (1/5th the standard starting dose) and halted when his data turned negative: resting heart rate up 3bpm, HRV down 7 points, sleep quality down 10%. He already had optimal metabolic markers, so the risk outweighed any benefit. This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached.
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