Not medical advice. Talk to your provider before using any peptide.
Full disclaimerThree weeks, then done. Johnson tried tirzepatide at 0.5mg weekly (1/5th the standard starting dose) and halted when his data turned negative: resting heart rate up 3bpm, HRV down 7 points, sleep quality down 10%. He already had optimal metabolic markers, so the risk outweighed any benefit. This is some of the best-documented peptide discontinuation data available, with exact biomarker numbers attached.
Counted from this protocol's own dose schedule, assuming 5mg vials and no vial shared between two doses. Not purchasing or medical advice.
Most users notice appetite suppression within days of first injection even at 2.5 mg. Some lose 2-5 lbs in week 1, often water weight and reduced GI volume. Community excitement is high; many are surprised how quickly food noise diminishes.
GI side effects peak at the 5 mg step for many users. Community calls this "the 5 mg wall." Most push through with slow titration. Visible weight loss validating the side effects. Body composition changes begin.
Many users find their "sweet spot" dose (often 7.5-12.5 mg). Food noise largely silent. Energy improving. Posts shift from "does it work?" to muscle preservation, clothing sizes, and dose decisions. SURMOUNT-5 results widely discussed: community validates head-to-head superiority over semaglutide.
For educational purposes only. Not medical advice. Consult a healthcare provider before starting any peptide protocol.