Peptide Schedule

Best Peptides for Weight Loss

The most effective peptides for fat loss and appetite suppression — from FDA-approved GLP-1 agonists to targeted fat-burning fragments.

1

Tirzepatide

Weight Loss~5 days half-life

The most powerful weight loss peptide available. Tirzepatide targets both GIP and GLP-1 receptors, producing up to 22.5% body weight loss in clinical trials — more than any single-agonist peptide.

Pros
  • FDA-approved (Mounjaro/Zepbound)
  • Superior weight loss vs semaglutide in head-to-head trials
  • Dual mechanism (GIP + GLP-1)
  • Once-weekly dosing
Cons
  • GI side effects during titration (nausea, diarrhea)
  • Expensive
  • Weight regain after discontinuation
View Tirzepatideguide →Tirzepatidecalculator →
2

Semaglutide

Weight Loss~7 days half-life

The most well-known GLP-1 agonist (Ozempic/Wegovy). Proven 15-17% body weight loss in trials with the most extensive long-term safety data of any weight loss peptide.

Pros
  • FDA-approved with extensive safety data
  • Proven cardiovascular benefits
  • Once-weekly dosing
  • Most accessible GLP-1 option
Cons
  • Less effective than tirzepatide in trials
  • GI side effects common during titration
  • Weight regain after stopping
View Semaglutideguide →Semaglutidecalculator →
3

Retatrutide

Weight Loss~6 days half-life

The first triple-agonist (GLP-1 + GIP + glucagon). Phase 2 trials showed up to 24% body weight loss — the highest of any peptide ever studied. The glucagon component also reduces liver fat.

Pros
  • Highest weight loss in any trial (24%)
  • Triple mechanism attacks fat from 3 angles
  • Reduces liver fat significantly
  • Once-weekly dosing
Cons
  • Still investigational — not yet FDA-approved
  • Limited long-term safety data
  • GI side effects during titration
View Retatrutideguide →Retatrutidecalculator →
4

AOD-9604

Weight Loss~2 hours half-life

A targeted fat-burning fragment of HGH (amino acids 177-191). Unlike GLP-1 agonists, it directly stimulates lipolysis without affecting appetite, blood sugar, or growth. GRAS safety status.

Pros
  • Directly targets fat metabolism
  • No effect on blood sugar or insulin
  • GRAS safety status
  • Can be combined with GLP-1 agonists
Cons
  • Weaker weight loss than GLP-1 agonists
  • Requires daily dosing on empty stomach
  • Less clinical data than GLP-1 drugs
View AOD-9604guide →AOD-9604calculator →

How We Ranked These

Ranked by clinical trial weight loss data, FDA approval status, mechanism breadth, and real-world accessibility. GLP-1 agonists lead because they have the strongest evidence base.

Beginner Recommendation

Start with Semaglutide for proven, accessible weight loss. Add AOD-9604 for targeted fat metabolism. Tirzepatide if you want maximum results.

View Weight Loss Stack→

Frequently Asked Questions