Peptide ScheduleSemaglutide vs Tirzepatide
Side-by-side comparison of dosage, benefits, and side effects.
Semaglutide is a GLP-1 receptor agonist — the same active ingredient in Ozempic and Wegovy. It mimics the hormone GLP-1, which regulates appetite and blood sugar. By slowing gastric emptying and acting on brain satiety centers, it dramatically reduces hunger and caloric intake. FDA-approved for both type 2 diabetes and obesity.
View full guide →Tirzepatide is a dual GIP/GLP-1 receptor agonist, sold as Mounjaro (diabetes) and Zepbound (obesity). It targets two incretin hormones simultaneously, producing greater weight loss than semaglutide in head-to-head trials (up to 22.5% vs 15%). GIP activation enhances fat metabolism and may improve tolerability compared to GLP-1-only drugs.
View full guide →At a Glance
| Attribute | Semaglutide | Tirzepatide |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| Half-Life | ~7 days | ~5 days |
| Route | Subcutaneous | Subcutaneous |
| Vial Sizes | 5mg, 10mg | 5mg, 10mg, 15mg |
| Beginner Dose | 250mcg Weekly | 2500mcg Weekly |
| Moderate Dose | 500mcg Weekly | 5000mcg Weekly |
| Aggressive Dose | 1000mcg Weekly | 10000mcg Weekly |
Key Differences
- Semaglutide is a single GLP-1 receptor agonist; Tirzepatide is a dual GIP/GLP-1 agonist.
- Tirzepatide shows greater average weight loss in clinical trials (up to 22.5% vs 14.9%).
- Both require slow titration, but Tirzepatide starts at higher doses (2.5mg vs 0.25mg).
- Semaglutide has longer market history and more long-term safety data.
When to Choose Semaglutide
- You want the most extensively studied GLP-1 option
- Your primary goal is moderate, sustainable weight loss
- You prefer a medication with longer real-world safety data
- Cost is a significant factor (often more accessible)
When to Choose Tirzepatide
- You want maximum weight loss potential
- You haven't responded adequately to single GLP-1 therapy
- You also want improvements in insulin sensitivity and blood sugar control
- You prefer the dual-mechanism approach for superior results
Can You Stack Semaglutide + Tirzepatide?
Semaglutide and Tirzepatide should not be stacked — they target overlapping pathways. Choose one based on your goals and response.