Peptide ScheduleSemaglutide vs Retatrutide
Side-by-side comparison of dosage, benefits, and side effects.
Semaglutide is a GLP-1 receptor agonist — the same active ingredient in Ozempic and Wegovy. It mimics the hormone GLP-1, which regulates appetite and blood sugar. By slowing gastric emptying and acting on brain satiety centers, it dramatically reduces hunger and caloric intake. FDA-approved for both type 2 diabetes and obesity.
View full guide →Retatrutide is the first triple-agonist peptide, targeting GLP-1, GIP, and glucagon receptors simultaneously — earning it the nickname 'Triple G.' In phase 2 trials, participants lost up to 24% of body weight at the highest dose, making it potentially the most powerful weight loss peptide ever studied. The glucagon component adds direct fat-burning and liver fat reduction beyond what GLP-1 alone achieves.
View full guide →At a Glance
| Attribute | Semaglutide | Retatrutide |
|---|---|---|
| Category | Weight Loss | Weight Loss |
| Half-Life | ~7 days | ~6 days |
| Route | Subcutaneous | Subcutaneous |
| Vial Sizes | 5mg, 10mg | 5mg, 10mg, 15mg |
| Beginner Dose | 250mcg Weekly | 1000mcg Weekly |
| Moderate Dose | 500mcg Weekly | 4000mcg Weekly |
| Aggressive Dose | 1000mcg Weekly | 8000mcg Weekly |
Key Differences
- Semaglutide targets GLP-1 only; Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors.
- Retatrutide showed up to 24% body weight loss in Phase 2 trials — the highest of any peptide to date.
- Semaglutide is FDA-approved and widely available; Retatrutide is still in clinical trials.
- Retatrutide's glucagon component may offer additional benefits for liver fat reduction.
When to Choose Semaglutide
- You want an FDA-approved, well-established option
- You want more long-term safety data available
- Accessibility and availability are priorities
- You're achieving adequate results with single GLP-1 therapy
When to Choose Retatrutide
- You want the most aggressive weight loss potential available
- You haven't responded well to single or dual agonists
- Liver fat reduction is an additional goal
- You're comfortable with a newer, less-studied peptide
Can You Stack Semaglutide + Retatrutide?
These should not be stacked as they share GLP-1 activity. Retatrutide already includes GLP-1 agonism.