Peptide ScheduleMetabolic Peptides
Mitochondrial peptides that enhance metabolic function and exercise capacity.
Metabolic peptides target your mitochondria — the energy factories inside every cell. As you age, mitochondrial function declines. These peptides aim to restore that capacity, improving exercise performance and metabolic flexibility.
MOTS-c is the most studied option. It's a mitochondria-derived peptide that activates AMPK (the same pathway triggered by exercise and metformin). Early research shows it may improve insulin sensitivity and fat oxidation.
This is a small category right now. Most metabolic peptides are still in early research phases with limited human data. If you're looking for metabolic support with more evidence, GLP-1 peptides in our weight loss category may be a better fit.
Quick Comparison
| Peptide | Route | Frequency | Half-Life | Status | Grade |
|---|---|---|---|---|---|
| Glucagon (GlucaGen) | Nasal | Single dose | 8-18 minutes | FDA Approved | A |
| L-Carnitine | SubQ | Daily | ~17 hours | FDA Approved | A |
| Lanreotide (Somatuline Depot) | SubQ | Monthly | ~23-30 days | FDA Approved | A |
| Octreotide (Sandostatin) | SubQ | 3x Daily | ~1.7-1.9 hours | FDA Approved | A |
| Desmopressin (DDAVP) | SubQ / Oral | Daily | 2.5-3.5 hours | FDA Approved | B |
| Ghrelin | SubQ | Daily | ~30 minutes | Research | B |
| MOTS-c | SubQ | 3x/week | ~12-15 hours | Preclinical | B |
| Pasireotide (Signifor) | SubQ | 2x Daily | ~12 hours | FDA Approved | B |
| Somatostatin (SST-14 and SST-28) | SubQ | Daily | ~1-3 minutes | Research | B |
| Vasopressin (Vasostrict) | SubQ | Daily | 10-20 minutes | FDA Approved | B |
| AICAR (Acadesine) | SubQ | Daily | ~2-3 hours | Research | C |
| Amylin (IAPP) | SubQ | 3x Daily | ~13-22 minutes | Research | C |
| BAM-15 | Oral | Daily | ~1.7 hours | Research | C |
| Bonothyrk | Oral | Daily | ~2-6 hours | Research | C |
| Cholecystokinin (CCK-8) | SubQ | Daily | 2-5 minutes | Research | C |
| Glandokort | Oral | Daily | ~1-4 hours | Research | C |
| Neuropeptide Y (NPY) | SubQ | Daily | ~20-30 minutes | Research | C |
| SLU-PP-332 | Intraperitoneal | Daily | ~4-6 hours | Research | C |
| Svetinorm | Oral | Daily | ~0.5-1 hour | Research | C |
All Metabolic Peptides(19)
MOTS-c
MOTS-c is a mitochondria-derived peptide encoded in mitochondrial DNA — making it one of the few known mitochondrial-...
L-Carnitine
L-Carnitine is a naturally occurring amino acid derivative that plays a central role in shuttling long-chain fatty ac...
SLU-PP-332
SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ) developed a...
AICAR (Acadesine)
AICAR (5-aminoimidazole-4-carboxamide ribonucleoside), also known as acadesine, is a cell-permeable nucleoside analog...
BAM-15
BAM-15 (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) is a small-molecule mitochondrial unc...
Glandokort
Glandokort is a peptide bioregulator derived from the adrenal glands of young animals through acid extraction and pur...
Bonothyrk
Bonothyrk is a bovine-derived peptide bioregulator containing a standardized extract of polypeptides from the parathy...
Svetinorm
Svetinorm is an oral peptide bioregulator developed by Prof.
Octreotide (Sandostatin)
Octreotide is a synthetic octapeptide analog of natural somatostatin, first approved by the FDA in 1988 for the treat...
Lanreotide (Somatuline Depot)
Lanreotide is a synthetic octapeptide analog of somatostatin, marketed as Somatuline Depot.
Ghrelin
Ghrelin is a 28-amino-acid peptide hormone discovered in 1999 as the endogenous ligand of the growth hormone secretag...
Somatostatin (SST-14 and SST-28)
Somatostatin (somatotropin release-inhibiting factor, SRIF) is a cyclic peptide hormone first isolated from ovine hyp...
Amylin (IAPP)
Amylin, also known as islet amyloid polypeptide (IAPP), is a 37-amino-acid peptide hormone produced by pancreatic bet...
Neuropeptide Y (NPY)
Neuropeptide Y (NPY) is a highly conserved 36-amino-acid peptide belonging to the pancreatic polypeptide family, whic...
Pasireotide (Signifor)
Pasireotide is a second-generation cyclohexapeptide somatostatin analog approved by the FDA in December 2012 for the ...
Desmopressin (DDAVP)
Desmopressin (DDAVP) is a first-line synthetic vasopressin analog approved by the FDA for the management of central d...
Cholecystokinin (CCK-8)
Cholecystokinin (CCK-8) is a sulfated octapeptide fragment of the 33-amino-acid gut hormone cholecystokinin, first is...
Glucagon (GlucaGen)
Glucagon is a naturally occurring 29-amino-acid peptide hormone secreted by the alpha cells of the pancreatic islets ...
Vasopressin (Vasostrict)
Vasopressin, also known as arginine vasopressin (AVP) or antidiuretic hormone (ADH), is a cyclic nonapeptide (Cys-Tyr...