Retatrutide Dosage Calculator

Retatrutide dosing starts at 1 mg weekly regardless of prior GLP-1 experience. The triple-receptor mechanism means your gut is adapting to three agonists at once, not just one. Even users who tolerated tirzepatide at high doses report rougher GI onboarding with retatrutide. Reconstitution math for common vial sizes: a 10 mg vial with 2 mL bacteriostatic water gives you 5 mg/mL. At that concentration, 1 mg equals 0.2 mL, which is 20 units on a standard 100-unit insulin syringe. A 4 mg dose would be 80 units. For the 12 mg maintenance dose, you'll want a 15 mg vial with 2 mL BAC water (7.5 mg/mL); 12 mg then equals 1.6 mL or 160 units. At 160 units, consider splitting across two injection sites to reduce volume discomfort. Track your resting heart rate from day one. The glucagon component raises energy expenditure, and HR is the clearest early signal of dose-dependent cardiovascular stress. If your resting pulse sits above 90 bpm for more than a week, hold the current dose before escalating. Evening injections let you sleep through peak nausea, which typically hits 4 to 8 hours post-injection.