Peptide ScheduleBPC-157 vs TB-500
Side-by-side comparison of dosage, benefits, and side effects.
BPC-157 (Body Protection Compound) is a 15-amino-acid peptide derived from a protein found in gastric juice. It accelerates healing of tendons, ligaments, muscles, nerves, and the gut lining. Research shows it promotes angiogenesis (new blood vessel formation), modulates nitric oxide, and upregulates growth factor receptors. It's stable in stomach acid, making it effective both orally and by injection.
View full guide →TB-500 is the active fragment of Thymosin Beta-4, a naturally occurring protein involved in tissue repair and regeneration. It promotes angiogenesis, reduces inflammation, and upregulates actin — a cell-building protein critical for healing. Unlike BPC-157, TB-500 works systemically, meaning it doesn't need to be injected near the injury site. It's commonly loaded at higher doses for 4-6 weeks, then maintained at half dose.
View full guide →At a Glance
| Attribute | BPC-157 | TB-500 |
|---|---|---|
| Category | Healing & Recovery | Healing & Recovery |
| Half-Life | ~30 min plasma (functional tissue activity ~4 hours) | ~5 hours plasma (functional tissue activity persists 7-10 days) |
| Route | Subcutaneous (near injury) or Oral | Subcutaneous or Intramuscular |
| Vial Sizes | 5mg, 10mg | 2mg, 5mg, 10mg |
| Beginner Dose | 250mcg 2x Daily | 2000mcg 2x/week |
| Moderate Dose | 500mcg Daily | 5000mcg 2x/week |
| Aggressive Dose | 750mcg 2x Daily | 7500mcg 2x/week |
Key Differences
- BPC-157 is a 15-amino acid peptide derived from gastric juice; TB-500 is a 7-amino acid fragment of Thymosin Beta-4.
- BPC-157 works best injected locally near the injury for targeted tissue repair; TB-500 is systemic and works regardless of injection site.
- BPC-157 promotes angiogenesis and tendon/ligament healing; TB-500 promotes cell migration and reduces inflammation system-wide.
- BPC-157 has a shorter half-life (~2 hours) requiring daily dosing; TB-500 has a longer half-life (~6 hours) allowing less frequent dosing.
When to Choose BPC-157
- Localized injuries like tendon tears, ligament sprains, or joint pain
- Gut healing and GI issues (BPC-157 was originally isolated from gastric juice)
- When you want targeted repair at a specific site
- Post-surgical recovery for a specific area
When to Choose TB-500
- Systemic inflammation or multiple injury sites
- General recovery and athletic performance
- When injection near the injury site isn't practical
- Cardiac tissue protection or hair growth support
Can You Stack BPC-157 + TB-500?
BPC-157 + TB-500 is the gold standard healing stack. They work synergistically — BPC-157 handles local repair while TB-500 manages systemic inflammation. Available as a pre-mixed blend for convenience.