Not medical advice. Talk to your provider before using any peptide.
Full disclaimerDerek (MPMD) GH Replication Stack
Derek's approach to replicating pharma-grade GH IGF-1 levels without actual GH. CJC-1295 DAC at 2.5mg twice weekly (Monday and Thursday) plus MK-677 at 25mg daily oral, both at bedtime. Target: IGF-1 around 500 ng/mL. The CJC-1295 DAC dose exceeds standard ranges. Regular IGF-1 bloodwork and fasting glucose monitoring required. Advanced users only.
Peptide Schedule Research TeamReviewed Apr 2026
For replicating high-dose growth hormone IGF-1 levels using peptides instead of pharmaceutical GH.
What This Protocol Does
CJC-1295 with DAC at 2.5mg twice weekly (Monday and Thursday) plus MK-677 at 25mg daily (oral). Both taken at bedtime. The target is IGF-1 levels around 500 ng/mL, which approximates what you'd get from pharmaceutical growth hormone at significant doses. CJC-1295 DAC has a long half-life (6-8 days), creating sustained GH elevation. MK-677 is an oral GH secretagogue that boosts GH release through the ghrelin pathway.
Who Should Use This
Advanced users only. The CJC-1295 DAC dose (2.5mg twice weekly, 5mg total) exceeds standard dosing ranges. Requires regular IGF-1 and fasting glucose bloodwork. MK-677 increases appetite and water retention significantly, so be prepared. Not for beginners, anyone with diabetes risk, or those with elevated IGF-1. Start with the Campbell Beginner GH Stack if this is your first GH protocol.
What the Research Says
CJC-1295 with DAC has clinical data showing sustained IGF-1 elevation for 6-8 days after a single injection (Teichman et al., PMID 16352683). MK-677 (ibutamoren) has Phase 2 data showing increased GH secretion and IGF-1 levels by 40-60% at 25mg daily (Chapman et al., PMID 9467534). Derek's combined protocol targets IGF-1 levels of ~500 ng/mL, which is well above the normal reference range (100-300 ng/mL for most adults). No published studies test this specific combination at these doses.
Important Notices
- CJC-1295 DAC at 2.5mg exceeds standard dosing — advanced users only
- MK-677 can increase appetite and water retention significantly
- Monitor IGF-1 levels and fasting glucose regularly
Protocol Overview
GH Replication Combo
CJC-1295 (DAC) + MK-677 (Ibutamoren)
Both at bedtime
Recommended Labwork
- IGF-1 levels
- Fasting glucose
- HbA1c
Dosing Details
| Peptide | Dose | Frequency | Route | Weeks |
|---|---|---|---|---|
CJC-1295 (DAC)Maint. | 2,500mcg | Custom Schedule | subcutaneous | Week 1+ |
MK-677 (Ibutamoren)Maint. | 25mg | Daily | oral | Week 1+ |
CJC-1295 (DAC): 2.5mg SubQ before bed Mon + Thu. Total 5mg/week. Target IGF-1 ~500 ng/mL.
MK-677 (Ibutamoren): 25mg oral daily before bed. "Diminishing returns once you pass 25mg per day."
Metrics Tracked
Schedule This Protocol
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