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CommunityMuscle GrowthReviewed Dosing

Derek (MPMD) GH Replication Stack

Derek's approach to replicating pharma-grade GH IGF-1 levels without actual GH. CJC-1295 DAC at 2.5mg twice weekly (Monday and Thursday) plus MK-677 at 25mg daily oral, both at bedtime. Target: IGF-1 around 500 ng/mL. The CJC-1295 DAC dose exceeds standard ranges. Regular IGF-1 bloodwork and fasting glucose monitoring required. Advanced users only.

Derek (MPMD)
Derek (MPMD)
How To Replicate HIGH Dose Pharma Grade GH With PeptidesJan 2020
2 phases·Ongoing·advanced

Peptide Schedule Research TeamReviewed Apr 10, 2026

Muscle Growth

For replicating high-dose growth hormone IGF-1 levels using peptides instead of pharmaceutical GH.

What This Protocol Does

CJC-1295 with DAC at 2.5mg twice weekly (Monday and Thursday) plus MK-677 at 25mg daily (oral). Both taken at bedtime. The target is IGF-1 levels around 500 ng/mL, which approximates what you'd get from pharmaceutical growth hormone at significant doses. CJC-1295 DAC has a long half-life (6-8 days), creating sustained GH elevation. MK-677 is an oral GH secretagogue that boosts GH release through the ghrelin pathway.

Who Should Use This

Advanced users only. The CJC-1295 DAC dose (2.5mg twice weekly, 5mg total) exceeds standard dosing ranges. Requires regular IGF-1 and fasting glucose bloodwork. MK-677 increases appetite and water retention significantly, so be prepared. Not for beginners, anyone with diabetes risk, or those with elevated IGF-1. Start with the Campbell Beginner GH Stack if this is your first GH protocol.

What the Research Says

CJC-1295 with DAC has clinical data showing sustained IGF-1 elevation for 6-8 days after a single injection (Teichman et al., PMID 16352683). MK-677 (ibutamoren) has Phase 2 data showing increased GH secretion and IGF-1 levels by 40-60% at 25mg daily (Chapman et al., PMID 9467534). Derek's combined protocol targets IGF-1 levels of ~500 ng/mL, which is well above the normal reference range (100-300 ng/mL for most adults). No published studies test this specific combination at these doses.

Important Notices

  • CJC-1295 DAC at 2.5mg exceeds standard dosing: advanced users only
  • MK-677 can increase appetite and water retention significantly
  • Monitor IGF-1 levels and fasting glucose regularly
Dosing Confidence
Reviewed Dosing
Experience Level
advanced

Protocol Overview

CJC-1295 (DAC)
2.5mg
12w
MK-677 (Ibutamoren)
25mg
12w
1 sub-stacks: each can be started independently

GH Replication Combo

CJC-1295 (DAC) + MK-677 (Ibutamoren)

Both at bedtime

Recommended Labwork

  • IGF-1 levels
  • Fasting glucose
  • HbA1c

Dosing Details

PeptideDoseFrequencyRouteWeeks
CJC-1295 (DAC)Maint.
2.5mgCustom SchedulesubcutaneousWeek 1+
MK-677 (Ibutamoren)Maint.
25mgDailyoralWeek 1+

CJC-1295 (DAC): 2.5mg SubQ before bed Mon + Thu. Total 5mg/week. Target IGF-1 ~500 ng/mL.

MK-677 (Ibutamoren): 25mg oral daily before bed. "Diminishing returns once you pass 25mg per day."

Metrics Tracked

Energy Level
Scale 0-10 · daily
Recovery Quality
Scale 0-10 · daily
Side Effects Noticed
boolean · per dose

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Peptide Profiles & Calculators

CJC-1295 (DAC)
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MK-677 (Ibutamoren)
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Related Muscle Growth Protocols

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Jay Campbell's Beginner GH Stack

CJC-1295 (No DAC) + Ipamorelin

Campbell's recommended starting point for newcomers. CJC-1295 (no DAC) plus ipamorelin at bedtime, 5 on / 2 off, 8 weeks on and 8 off. He calls it "extensively studied." The same combo shows up in both his muscle growth and fat loss stack lists, which tells you something about its versatility.

Growth HormoneReviewed DosingBeginner
2 phases·8 weeks
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Similar Protocols

Jay Campbell's Beginner GH Stack
2 peptides · 8w
Dr. Koniver's GH Secretagogue Bedtime Stack
3 peptides · 12w

Frequently Asked Questions

Derek designed it to replicate the IGF-1 levels you'd get from injecting pharmaceutical growth hormone, but using peptides that stimulate your own GH production instead. The target of ~500 ng/mL IGF-1 is what you might see on moderate-to-high dose exogenous GH.

It exceeds standard dosing ranges (typically 1-2mg per week total). Derek acknowledges this is an aggressive protocol. Start lower and titrate up based on IGF-1 bloodwork. If IGF-1 exceeds 500 ng/mL or fasting glucose rises, reduce the dose.

Yes. MK-677 works through the ghrelin (hunger hormone) pathway. Most users report significantly increased appetite, especially in the first 2-4 weeks. Water retention and bloating are also common. These effects can be managed but not eliminated at 25mg daily.

Campbell uses CJC-1295 without DAC + ipamorelin at moderate doses. Derek uses CJC-1295 with DAC (longer-acting) + MK-677 (oral, ghrelin-based) at aggressive doses. Campbell's is the beginner version; Derek's targets experienced users who want maximum GH output and accept higher risk.