Peptide ScheduleSemax vs Selank
Side-by-side comparison of dosage, benefits, and side effects.
Semax is a synthetic peptide analog of ACTH (adrenocorticotropic hormone) developed in Russia for stroke treatment and cognitive enhancement. It powerfully increases BDNF (brain-derived neurotrophic factor) — the key protein for learning, memory, and neuroplasticity. Unlike ACTH, Semax does not affect cortisol or the adrenal glands. It's approved in Russia for stroke, cognitive disorders, and peptic ulcers.
View full guide →Selank is a synthetic peptide based on the naturally occurring immune molecule tuftsin, developed at the Institute of Molecular Genetics in Russia. It's a potent anxiolytic (anti-anxiety) that modulates serotonin, BDNF (brain-derived neurotrophic factor), and enkephalins without the sedation or addiction risk of benzodiazepines. It enhances cognitive function, reduces anxiety, and supports immune function simultaneously.
View full guide →At a Glance
| Attribute | Semax | Selank |
|---|---|---|
| Category | Cognitive | Cognitive |
| Half-Life | ~2-3 min (IV) | ~2-3 min (IV) |
| Route | Subcutaneous or Nasal | Subcutaneous or Nasal |
| Vial Sizes | 5mg | 5mg |
| Beginner Dose | 200mcg Daily | 250mcg Daily |
| Moderate Dose | 500mcg Daily | 500mcg Daily |
| Aggressive Dose | 1000mcg Daily | 750mcg 2x Daily |
Key Differences
- Semax powerfully increases BDNF for learning and neuroplasticity; Selank modulates serotonin and GABA for anxiolytic effects.
- Semax is more stimulating and focus-oriented; Selank is calming and anti-anxiety without sedation.
- Both are available as nasal sprays for needle-free use.
- Semax is better for acute cognitive tasks; Selank is better for sustained calm focus and stress resilience.
When to Choose Semax
- Your primary goal is enhanced learning, memory, and focus
- You want increased BDNF for neuroplasticity
- You need acute mental performance (studying, work sprints)
- Cognitive decline prevention is a priority
When to Choose Selank
- Anxiety reduction without sedation is your primary goal
- You want calm, sustained focus rather than stimulation
- Stress resilience and emotional regulation are priorities
- You prefer a more gentle cognitive enhancer
Can You Stack Semax + Selank?
Semax + Selank is the classic nootropic peptide stack. Semax provides the cognitive boost while Selank keeps anxiety in check — complementary mechanisms without interference.