Peptide Schedule
Selank7 residuesTKPRPGPEach bubble = one amino acid. Size = residue mass. Color = chemical class.Selank
Benefits
About Selank
Selank is a synthetic peptide based on the naturally occurring immune molecule tuftsin, developed at the Institute of Molecular Genetics in Russia. It's a potent anxiolytic (anti-anxiety) that modulates serotonin, BDNF (brain-derived neurotrophic factor), and enkephalins without the sedation or addiction risk of benzodiazepines. It enhances cognitive function, reduces anxiety, and supports immune function simultaneously.
Who Should Consider Selank
- Adults with generalized anxiety disorder seeking non-benzodiazepine options
- Individuals looking for cognitive enhancement and improved focus
- Those experiencing stress-related cognitive decline
- People seeking combined anxiolytic and immune support
- Adults with neurasthenia or chronic fatigue-related anxiety
What to Expect
Initial anxiolytic effects may be noticed within hours of first dose. Mild calming without sedation. Some users report improved mental clarity same day.
Anxiety reduction becomes more consistent. Improved stress resilience and focus. Serotonin and enkephalin modulation begins to stabilize.
Nootropic effects strengthen — better working memory, verbal fluency, and focus. BDNF upregulation contributes to cognitive gains. Immune function improvements may begin.
Full anxiolytic and nootropic effects. Mood stabilization through GABA and serotonin modulation. Many protocols recommend cycling off after 2-4 weeks.
Some residual cognitive and anxiolytic benefits may persist for 1-2 weeks due to BDNF-driven neuroplastic changes. Cycle can be repeated after a 2-week break.
Dosing Protocol
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 250mcg | Daily |
| Moderate | 500mcg | Daily |
| Aggressive | 750mcg | 2x Daily |
Note: Anxiolytic peptide. Tuftsin analog. Also available as nasal spray. Modulates BDNF and serotonin.
Pharmacokinetics
Source: Plasma t½ ~2-3 min; intranasal bioavailability ~92.8% with rapid CNS penetration via olfactory pathway (Semenova et al. 2018 PMID 29787664)
Loading the interactive decay curve.
Side Effects
Very well-tolerated. No sedation, no addiction potential. Rare: mild fatigue. Available as nasal spray for needle-free use.
Contraindications
- Pregnancy or breastfeeding — insufficient safety data
- Known hypersensitivity to tuftsin or selank
- Active autoimmune conditions — may alter immune regulation
- Children under 18 — not studied in pediatric populations
- Concurrent use of immunosuppressive therapy — may interfere with intended immune modulation
Drug Interactions
- Benzodiazepines (diazepam, lorazepam) — selank may potentiate anxiolytic effects; dose adjustment may be needed
- SSRIs and SNRIs — additive serotonergic effects possible; monitor for excess serotonin activity
- Enkephalinase inhibitors — selank inhibits enkephalin degradation, potential for additive opioid-pathway effects
- Immunomodulatory drugs — may alter intended immune response when combined
- GABAergic agents (gabapentin, pregabalin) — potential for additive CNS effects due to GABA receptor modulation
Molecular Profile
Related Peptides
References
- Efficacy and mechanisms of selank in generalized anxiety disorders and neurasthenia (Zozulya et al. 2008)PubMed 18454096
- Selank affects expression of genes involved in GABAergic neurotransmission (Kasian et al. 2016)PubMed 26847159
- Selank protects against ethanol-induced memory impairment via BDNF regulation (Volkova et al. 2019)PubMed 31625062
- Peptide-based anxiolytics: molecular aspects of selank biological activity (Uchakina et al. 2018)PubMed 30255741
- Immunomodulatory effects of selank in patients with anxiety-asthenic disorders (Ershov et al. 2008)PubMed 18577961
- Comparison of selank pharmacological effects after intranasal and intraperitoneal administration (Semenova et al. 2018)PubMed 29787664