Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202612 Citations
MOTS-c activates the same AMPK pathway triggered by exercise, making it one of the few true exercise mimetics. Preclinical data shows fat loss and insulin sensitization in mice; community users report improved endurance and glucose control within 2 to 4 weeks.
5mg · 3x/week
Summary: Add 2mL BAC water to your 5mg vial. Draw to 200.0 units on a U-100 syringe for a 5mg dose. This vial will last 1 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 5mg | 3x/week |
| Moderate | 10mg | 3x/week |
| Aggressive | 10mg | 5x/week |
Reconstitution math for a 10 mg vial: add 2 mL bacteriostatic water to get 5 mg/mL. A full 100-unit (1.0 mL) insulin syringe then delivers exactly 5 mg. For the 10 mg dose, you'll draw 200 units (2.0 mL), which means splitting between two injection sites at 100 units each. One 10 mg vial equals one dose at the intermediate level. For 5 mg vials: add 1 mL BAC water for the same 5 mg/mL concentration. A full syringe equals the full vial. The thing most beginners miss is timing. MOTS-c fires up AMPK, and that energy signal will keep you awake if you inject past early afternoon. Dose upon waking or 30 to 60 minutes before training. Never after 2 PM. Store lyophilized powder at -20 degrees Celsius. Once reconstituted, refrigerate at 2 to 8 degrees Celsius and use within 28 days. Confirm vendor labels are in mg, not mcg; the community doses MOTS-c in milligrams and a mg/mcg mix-up creates a 1,000-fold error.
Dosing based on Community dosing consensus from peptide research communities — 16 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
MOTS-c activates the same AMPK pathway triggered by exercise, making it one of the few true exercise mimetics. Preclinical data shows fat loss and insulin sensitization in mice; community users report improved endurance and glucose control within 2 to 4 weeks.