Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20266 Citations
IGF-1 DES67 residuesTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSAEach bubble = one amino acid. Size = residue mass. Color = chemical class.IGF-1 DES delivers roughly 10x the receptor potency of native IGF-1 by skipping binding protein attachment entirely. A 20-to-30-minute half-life makes post-workout intramuscular injection non-negotiable. Community results point to visible localized growth by week 3, but hypoglycemia management is the price of entry.
50mcg · Training days only (4-5x/week)
Summary: Add 1mL BAC water to your 0.1mg vial. Draw to 50.0 units on a U-100 syringe for a 50mcg dose. This vial will last 2 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 50mcg | Training days only (4-5x/week) |
| Moderate | 80mcg | Training days only (4-5x/week) |
| Aggressive | 120mcg | Training days only (4-5x/week) |
Reconstitution math for the two common vial sizes. For a 0.1 mg (100 mcg) vial: add 1 mL bacteriostatic water. Concentration becomes 100 mcg/mL. A 50 mcg dose is 50 units on a U-100 insulin syringe. For a 1 mg vial: add 2 mL bacteriostatic water. Concentration becomes 500 mcg/mL. A 50 mcg dose is 10 units; 80 mcg is 16 units; 100 mcg is 20 units on a U-100 syringe. Timing is everything with DES. You have a 10-to-15-minute window after finishing the target muscle group to get the injection done. Prep your syringe before your last working set so you're ready. The ultra-short half-life means delays past 15 minutes post-workout significantly reduce local receptor exposure. Vendor quality is a real concern. The research-chemical market for DES has documented purity inconsistencies. Get a Certificate of Analysis from Janoshik or Colmaric before committing to a vial. Start with a low test dose (20 to 30 mcg) to assess your blood glucose response before running a full protocol.
Dosing based on Community dosing consensus from peptide research communities — 9 published references.View all sources →
Cross-check your IGF-1 DES reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
IGF-1 DES delivers roughly 10x the receptor potency of native IGF-1 by skipping binding protein attachment entirely. A 20-to-30-minute half-life makes post-workout intramuscular injection non-negotiable. Community results point to visible localized growth by week 3, but hypoglycemia management is the price of entry.
