Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20265 Citations
PE-22-287 residuesGVSWGLREach bubble = one amino acid. Size = residue mass. Color = chemical class.PE-22-28 blocks TREK-1 potassium channels with 300-fold greater potency than its parent compound spadin. Rodent studies show antidepressant-like effects within four days and a functional duration around 23 hours. No human trial data exists; all dosing is community-derived at this time.
100mcg · Daily
Summary: Add 2mL BAC water to your 5mg vial. Draw to 4.0 units on a U-100 syringe for a 100mcg dose. This vial will last 50 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 100mcg | Daily |
| Moderate | 200mcg | Daily |
| Aggressive | 400mcg | Daily |
Start with a 5 mg vial and 2 mL of bacteriostatic water. That gives you 2,500 mcg per mL, or 25 mcg per unit on a U-100 insulin syringe. For 100 mcg you'll pull 4 units; for 200 mcg, pull 8 units; for 400 mcg, pull 16 units. If you're going intranasal, swap BAC water for bacteriostatic saline. Regular BAC water burns. Get a nasal spray atomizer that delivers a consistent spray volume so you can calculate dose per pump. With a 10 mg vial at 2 mL reconstitution, the math doubles: 5,000 mcg per mL, so 50 mcg per unit. A 200 mcg dose is then 4 units; 400 mcg is 8 units. The 10 mg vial at 200 mcg daily lasts about 50 days, which means one vial covers your entire 4-week cycle with room to spare. Vendor quality matters more than usual here. PE-22-28 is niche, few vendors carry it, and Peptide Sciences closed in March 2026. Request a CoA with HPLC purity above 98% and mass spec confirmation. Store lyophilized powder at minus 20 degrees Celsius; reconstituted solution at 2 to 8 degrees Celsius, use within 30 days.
Dosing based on Very limited data: dose based on preclinical and anecdotal reports — 8 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
PE-22-28 blocks TREK-1 potassium channels with 300-fold greater potency than its parent compound spadin. Rodent studies show antidepressant-like effects within four days and a functional duration around 23 hours. No human trial data exists; all dosing is community-derived at this time.
