Peptide Schedule
Cortagen5 residuesAEDPGEach bubble = one amino acid. Size = residue mass. Color = chemical class.Cortagen Dosage Calculator
Cortagen is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro, designed as a simplified bioregulator based on the active components found in Cortexin.
5mcg · Daily
Summary: Add 0mL BAC water to your 10mg vial. Draw to < 0.1 units on a U-100 syringe for a 5mcg dose. This vial will last 0 doses.
Cycle Planner
Cortagen Pharmacokinetics
Pharmacokinetics — Active Dose Over Time
t½ = ~0.5 hours (estimated; no formal PK studies published)Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Cortagen Dosing Protocol
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 5mg | Daily |
| Moderate | 10mg | Daily |
| Aggressive | 20mg | Daily |
Note: Cortagen (Ala-Glu-Asp-Pro) is a synthetic tetrapeptide bioregulator developed by Vladimir Khavinson. It was derived through directed synthesis based on amino acid analysis of Cortexin, a polypeptide extract from the cerebral cortex. Oral capsule — no reconstitution required. Standard protocols involve 10-30 day courses taken 2-3 times per year.
About Cortagen
Cortagen is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro, designed as a simplified bioregulator based on the active components found in Cortexin. It was developed by Professor Vladimir Khavinson's research group as part of a broader program to create tissue-specific short peptides that can influence gene expression in target organs. In animal studies, Cortagen has shown tissue-specific activity for neural tissue. When added to organotypic cultures, it selectively stimulated the growth of explants from rat brain cortex but not from other organs. In a sciatic nerve transection model, intramuscular Cortagen injections increased nerve fiber growth rate by 27% and conduction velocity by 40% over a 10-day treatment period. Microarray analysis in mice revealed that a 5-day course of Cortagen affected the expression of 110 known genes across multiple functional categories. The peptide also demonstrates epigenetic activity, inducing selective deheterochromatinization — the decondensation of aged, silenced chromatin regions — which may reactivate repressed genes in older individuals. The evidence base consists almost entirely of Russian-language publications, animal studies, and in vitro work. No controlled human clinical trials have been published in international peer-reviewed journals.