Peptide Schedule
SNAP-89 residuesEEEMQRRADEach bubble = one amino acid. Size = residue mass. Color = chemical class.SNAP-8 Dosage Calculator
SNAP-8 (Acetyl Octapeptide-3) is an eight-amino-acid peptide designed to reduce the appearance of expression lines and wrinkles through a mechanism similar to botulinum toxin — but without injections.
100mcg · Daily
Summary: Add 0mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 100mcg dose. This vial will last 0 doses.
Cycle Planner
SNAP-8 Pharmacokinetics
SNAP-8 Dosing Protocol
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 100mcg | Daily |
| Moderate | 250mcg | Daily |
| Aggressive | 500mcg | Daily |
Note: Topical anti-wrinkle peptide, also known as Acetyl Octapeptide-3. Typically applied in serum form at 3-10% concentration twice daily. The dosing tiers above reflect research-grade topical solution amounts per application in mcg. At 10% concentration, clinical studies report up to 63% wrinkle depth reduction over 28 days. Best applied to clean, dry skin on expression-line areas (forehead, crow's feet, glabella).
About SNAP-8
SNAP-8 (Acetyl Octapeptide-3) is an eight-amino-acid peptide designed to reduce the appearance of expression lines and wrinkles through a mechanism similar to botulinum toxin — but without injections. Its sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) mimics the N-terminal end of SNAP-25, a protein that forms part of the SNARE complex responsible for neurotransmitter release at neuromuscular junctions. By competing with native SNAP-25 for binding within the SNARE complex, SNAP-8 destabilizes vesicle fusion and reduces acetylcholine release, which in turn attenuates the muscle contractions that cause dynamic wrinkles. Unlike Botox, SNAP-8 does not cleave SNAP-25 or paralyze muscles — it modulates contraction intensity, allowing natural facial expressions while softening lines. In vitro studies show SNAP-8 inhibits glutamate release by up to 43% at 1.5 mM concentration, and in vivo human trials with 10% topical SNAP-8 cream reported an average wrinkle depth reduction of 35%, with some subjects reaching 63% reduction over 28 days. SNAP-8 is approximately 30% more active than its six-amino-acid parent peptide Argireline (Acetyl Hexapeptide-8) in comparative testing. The primary limitation is skin penetration: as a hydrophilic peptide, SNAP-8 struggles to cross the lipophilic stratum corneum efficiently. Advanced delivery systems such as multiple emulsions, liposomes, or microneedling can improve dermal absorption. SNAP-8 is considered a cosmeceutical ingredient and is not FDA-approved for any medical indication. It remains a research-only compound with a strong safety profile in topical applications but limited peer-reviewed clinical validation independent of manufacturer-funded studies.