Peptide Schedule
NA-Semax Amidate7 residuesMEHFPGPEach bubble = one amino acid. Size = residue mass. Color = chemical class.

NA-Semax Amidate Dosage Calculator

CognitiveNasalResearch~5-10 min half-life

NA-Semax Amidate (N-Acetyl Semax Amidate) is a modified version of the Russian nootropic peptide Semax, engineered with two chemical changes that set it apart from the original.

Enhanced stability and bioavailability over standard Semax3-5x more potent than unmodified Semax per microgramUpregulates BDNF and NGF for learning, memory, and neuroplasticityNeuroprotective effects demonstrated in ischemia models2 weeks on / 2 weeks off

100mcg · Daily

100500
2.0 units
100 units (1mL)
Concentration
5,000
mcg/mL
Draw Volume
0.020
mL
Syringe Units
2.0
units
Doses / Vial
100
doses
Very small draw (2.0 units) — difficult to measure accurately. Consider using less BAC water for a more concentrated solution.
Try 1mL BAC water for an easier-to-measure draw.

Summary: Add 2mL BAC water to your 10mg vial. Draw to 2.0 units on a U-100 syringe for a 100mcg dose. This vial will last 100 doses.

Cycle Planner

Intranasal. Typical beginner frequency: daily.

NA-Semax Amidate Pharmacokinetics

Pharmacokinetics — Active Dose Over Time

t½ = ~5-10 min (intranasal)
50%25%12.5%100%75%50%25%0%08m15m23m30m38mTime after injectionDose remaining
After 1 half-life (8m): 50% remainsAfter 2 half-lives (15m): 25% remainsAfter 3 half-lives (23m): 12.5% remains
At a 300mcg dose: 50% = 150mcg remaining after 8m. Recommended frequency: Daily.

Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.

NA-Semax Amidate Dosing Protocol

LevelDose / InjectionFrequency
Beginner100mcgDaily
Moderate300mcgDaily
Aggressive600mcgDaily

Note: Enhanced Semax with N-acetyl + C-terminal amide modifications. 3-5x more potent than standard Semax — reduce dose accordingly. Intranasal preferred. Cycle 10-20 days on, 10-20 days off.

About NA-Semax Amidate

NA-Semax Amidate (N-Acetyl Semax Amidate) is a modified version of the Russian nootropic peptide Semax, engineered with two chemical changes that set it apart from the original. The N-terminal acetyl group and C-terminal amide cap protect the peptide from enzymatic breakdown by aminopeptidases and carboxypeptidases, giving it greater stability in brain tissue and a longer effective window compared to unmodified Semax. The core sequence — ACTH(4-10) with a PGP extension — is identical to standard Semax, so the underlying mechanism is the same: it binds to melanocortin receptors and upregulates BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) in the hippocampus and basal forebrain. What the acetylation and amidation change is the pharmacokinetic profile. Preliminary data suggests NA-Semax Amidate resists degradation in brain tissue longer than standard Semax, which may translate to a more sustained neurotrophic effect per dose. Potency is estimated at 3-5x that of standard Semax. This is a practical concern — users who dose NA-Semax Amidate at the same microgram range as regular Semax often report overstimulation, anxiety, and irritability. Starting at 100mcg intranasally and titrating up is the standard approach. Beyond the neurotrophic effects, the peptide interacts with serotonergic, dopaminergic, and enkephalin signaling pathways, which may explain the reported improvements in mood and stress resilience alongside cognitive enhancement.

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Frequently Asked Questions