Peptide Schedule
MGF (Mechano Growth Factor)24 residuesYQPPSTNKNTKSQRRKGSTFEERKEach bubble = one amino acid. Size = residue mass. Color = chemical class.MGF (Mechano Growth Factor) Dosage Calculator
MGF (Mechano Growth Factor) is the 24-amino-acid C-terminal peptide derived from the IGF-1Ec splice variant.
100mcg · Daily
Summary: Add 1mL BAC water to your 2mg vial. Draw to 5.0 units on a U-100 syringe for a 100mcg dose. This vial will last 20 doses.
Cycle Planner
MGF (Mechano Growth Factor) Pharmacokinetics
Pharmacokinetics — Active Dose Over Time
t½ = ~5-7 minutesDisclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
MGF (Mechano Growth Factor) Dosing Protocol
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 100mcg | Daily |
| Moderate | 200mcg | Daily |
| Aggressive | 300mcg | Daily |
Note: Extremely short half-life — must be injected immediately post-workout for any localized effect. Most users prefer the PEGylated version (PEG-MGF) for practical dosing. Inject near the target muscle site, not systemically. Cycle 4-6 weeks on, 4 weeks off. Store reconstituted vial refrigerated and use within 7-10 days.
About MGF (Mechano Growth Factor)
MGF (Mechano Growth Factor) is the 24-amino-acid C-terminal peptide derived from the IGF-1Ec splice variant. When muscle tissue is stretched, damaged, or subjected to mechanical load, the IGF-1 gene undergoes alternative splicing to produce the Ec isoform — releasing MGF locally at the site of injury. Unlike systemic IGF-1, MGF acts as an immediate-early repair signal: it activates quiescent muscle satellite (stem) cells, pushing them into the cell cycle to begin proliferating without triggering premature differentiation. This distinction is important — satellite cell activation is the rate-limiting step in muscle repair. In preclinical models, MGF expression peaks within 1-6 hours of mechanical stimulus and returns to baseline within 24-72 hours, after which the IGF-1Ea isoform takes over to drive differentiation and protein synthesis. The synthetic MGF peptide replicates this E-domain signal. However, its native half-life is only 5-7 minutes due to rapid enzymatic degradation, making practical dosing difficult. Most research protocols call for localized injection near the trained muscle immediately post-exercise. Beyond skeletal muscle, MGF has shown neuroprotective activity in aging mouse brain tissue and plays a role in cardiac tissue repair after ischemic injury. All current evidence is from cell culture and animal studies — no human clinical trials have been completed.