Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202611 Citations
Melanotan II activates five melanocortin receptors, producing UV-free tanning, libido enhancement, and appetite suppression. Phase 1 data confirmed its activity in the 1990s, but it never reached approval. Nausea during loading is near-universal. Community protocols dominate dosing guidance worldwide today.
250mcg · Daily
Summary: Add 2mL BAC water to your 10mg vial. Draw to 5.0 units on a U-100 syringe for a 250mcg dose. This vial will last 40 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 250mcg | Daily |
| Moderate | 500mcg | Daily |
| Aggressive | 1mg | Daily |
Start at 100 to 250 mcg for the first few days and inject before bed. Nausea is almost guaranteed during loading, and sleeping through it is the simplest solution. Increase by 250 mcg every 3 to 5 days only once you're tolerating the current dose. Reconstitution math for a 10 mg vial with 2 mL bacteriostatic water: that gives you 5,000 mcg per mL, or 5 mcg per unit on a U-100 insulin syringe. So 250 mcg equals 5 units (0.05 mL), 500 mcg equals 10 units (0.10 mL), and 1,000 mcg equals 20 units (0.20 mL). The thing most beginners miss is that UV exposure matters. MT-II primes your melanocytes, but you still need 10 to 15 minutes of sun or UV exposure during loading to activate melanin and get even pigmentation. Without it, tanning will be patchy and weighted toward areas that already have more melanocytes (face, arms, freckles). Store lyophilized powder at 2 to 8 degrees Celsius. After reconstitution, refrigerate and use within 30 days. Never use nasal spray formulations; a 2025 case report [6] documented oral mucosal melanoma in a 22-year-old using MT-II nasally.
Dosing based on Community dosing consensus from peptide research communities — 17 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Melanotan II activates five melanocortin receptors, producing UV-free tanning, libido enhancement, and appetite suppression. Phase 1 data confirmed its activity in the 1990s, but it never reached approval. Nausea during loading is near-universal. Community protocols dominate dosing guidance worldwide today.