How many units of Lanreotide (Somatuline Depot) should I draw?

It depends on your vial size, BAC water, and dose. For a 60mg vial with 0mL BAC water, a beginner dose of 60mg is typically 0 units on a U-100 syringe. Use the calculator above for your exact numbers.

How much BAC water should I add to Lanreotide (Somatuline Depot)?

The standard amount is 0mL of bacteriostatic water for a 60mg vial. More water gives a more dilute solution — easier to measure small doses. Less water means fewer injections per vial. Adjust the BAC water slider in the calculator to see how it changes your syringe units.

How long does a Lanreotide (Somatuline Depot) vial last?

At a beginner dose of 60mg monthly, a 60mg vial lasts about 1000 doses. The calculator shows exact doses per vial for your selected tier.

What syringe should I use for Lanreotide (Somatuline Depot)?

Most people use a U-100 insulin syringe (1mL / 100 units). For very small doses, a U-50 or U-30 syringe gives better precision. The calculator adjusts units automatically for whichever syringe you pick.

Lanreotide (Somatuline Depot) Dosage Calculator

MetabolicInjectionFDA Approved~23-30 days half-life

Lanreotide is a synthetic octapeptide analog of somatostatin, marketed as Somatuline Depot.

Normalizes GH and IGF-1 levels in 50-70% of acromegaly patientsSignificantly prolongs progression-free survival in GEP-NETs (CLARINET trial: 53% risk reduction)Reduces pituitary tumor volume by ≥20% in ~63% of patients (PRIMARYS trial)Once-monthly dosing with pre-filled syringe — no reconstitution required

Vial Size

BAC Water (mL)

Dosing Level

60mcg · Monthly

Custom Dose (mcg) — optional

Syringe Type

0.0 units

100 units (1mL)

Concentration

mcg/mL

Draw Volume

< 0.001

Syringe Units

< 0.1

units

Doses / Vial

doses

Summary: Add 0mL BAC water to your 60mg vial. Draw to < 0.1 units on a U-100 syringe for a 60mcg dose. This vial will last 0 doses.

Cycle Planner

Cycle Length (weeks)

Price Per Vial ($) — optional

Deep subcutaneous (upper outer quadrant of buttock). Typical beginner frequency: monthly.

Lanreotide (Somatuline Depot) Pharmacokinetics

Pharmacokinetics — Active Dose Over Time

t½ = ~23-30 days (depot formulation)

After 1 half-life (27d): 50% remainsAfter 2 half-lives (53d): 25% remainsAfter 3 half-lives (80d): 12.5% remains

At a 90mcg dose: 50% = 45mcg remaining after 27d. Recommended frequency: Monthly.

Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.

Lanreotide (Somatuline Depot) Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	60mg	Monthly
Moderate	90mg	Monthly
Aggressive	120mg	Monthly

Note: Lanreotide is administered as a deep subcutaneous injection every 28 days, not weekly. The "Weekly" frequency is used as the closest valid option — actual dosing is once every 4 weeks (q28d). Available as a pre-filled syringe (Somatuline Depot) in 60mg, 90mg, and 120mg strengths. Dose selection depends on GH/IGF-1 levels for acromegaly or tumor grade for GEP-NETs. Do not mix or dilute — inject the full syringe at room temperature into the upper outer quadrant of the buttock.

About Lanreotide (Somatuline Depot)

Lanreotide is a synthetic octapeptide analog of somatostatin, marketed as Somatuline Depot. It binds primarily to somatostatin receptor subtypes 2 (SST2) and 5 (SST5), inhibiting growth hormone (GH) secretion, reducing IGF-1 levels, and exerting antiproliferative effects on neuroendocrine cells. FDA-approved since 2007 for acromegaly and since 2014 for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The depot formulation uses a supersaturated solution that forms a gel deposit at the injection site, providing sustained drug release over 28 days.

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