Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20267 Citations
Orexin (Hypocretin)33 residuesQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTMEach bubble = one amino acid. Size = residue mass. Color = chemical class.Orexin-A is the neuropeptide behind your brain's wakefulness switch. Two FDA-approved drugs target its receptors to treat insomnia. Published human doses (~1,550 mcg intranasal) showed wakefulness effects in narcolepsy patients, but community doses (10-50 mcg) sit 30-178x below that threshold.
10mcg · Daily
Summary: Add 2mL BAC water to your 0.5mg vial. Draw to 4.0 units on a U-100 syringe for a 10mcg dose. This vial will last 50 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 10mcg | Daily |
| Moderate | 30mcg | Daily |
| Aggressive | 50mcg | 2x Daily |
Orexin-A comes as a lyophilized powder. Reconstitute a 1 mg vial with 2 mL bacteriostatic water. That gives you 500 mcg/mL, or 5 mcg per unit on a 100-unit insulin syringe. At the community starting dose of 10 mcg, that's 2 units drawn into a syringe and loaded into a nasal spray device. At 30 mcg, draw 6 units; at 50 mcg, draw 10 units. The reconstitution step matters more here than with most peptides. Orexin-A has two disulfide bonds and an N-terminal pyroglutamyl modification. Shaking the vial can break disulfide connectivity and destroy bioactivity. Add bacteriostatic water slowly down the vial wall. Swirl gently. Never vortex. Morning dosing only. This peptide activates every arousal circuit in the brain. Afternoon or evening use at any effective dose is asking for insomnia. One more thing worth knowing: community doses (10-50 mcg) are 30-178x below the only human doses that showed CNS effects. Published human studies used ~1,550-1,780 mcg intranasally. At that dose, a 5 mg vial gives you roughly 2.8 doses at ~$32 each from consumer sources.
Dosing based on Research peptide; clinical orexin agonists differ structurally and in dose — 10 published references.View all sources →
Cross-check your Orexin (Hypocretin) reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Orexin-A is the neuropeptide behind your brain's wakefulness switch. Two FDA-approved drugs target its receptors to treat insomnia. Published human doses (~1,550 mcg intranasal) showed wakefulness effects in narcolepsy patients, but community doses (10-50 mcg) sit 30-178x below that threshold.
