Neuropeptide Y (NPY) Dosage Calculator

Start with the most important practical point: subcutaneous NPY will not produce appetite or anxiety effects. Those endpoints require intranasal delivery through an olfactory-targeted device, not a standard nasal spray bottle. The clinical trials used a custom OptiNose-type device. Reconstitution math for SC research use: a 2 mg vial reconstituted with 2 mL bacteriostatic water gives 1 mg/mL (1000 mcg/mL). At the beginner dose of 50 mcg, that's 5 units on a 100-unit insulin syringe. Moderate dose (100 mcg) is 10 units. Aggressive (200 mcg) is 20 units. With a 1 mg vial in 2 mL, concentrations halve; double your unit counts. NPY degrades fast. Plasma half-life is 20 to 25 minutes because DPP-IV clips the N-terminal Tyr-Pro dipeptide almost immediately. Reconstitute fresh, store at 2 to 8 degrees Celsius, use within 14 days, and minimize needle punctures through the stopper. Every freeze-thaw cycle accelerates degradation. The sourcing situation is unusual. No gray-market peptide vendor stocks NPY. Lab-grade material from Hello Bio, Thermo Fisher, or Tocris runs $337 to $537 per milligram. Verify CoA with HPLC purity at or above 95% and mass spec confirming MW 4272.7 Da.