Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20264 Citations
Nesiritide (Natrecor)32 residuesSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRHEach bubble = one amino acid. Size = residue mass. Color = chemical class.Nesiritide (Natrecor) is a recombinant BNP that lowers pulmonary pressures within 15 minutes in acute heart failure. FDA-approved in 2001 but discontinued after ASCEND-HF (n=7,141) showed no mortality benefit. Hospital-only IV drug with no approved community use or self-administration potential.
2mcg · IV bolus + 0.01 mcg/kg/min infusion
Summary: Add 0mL BAC water to your 1.5mg vial. Draw to < 0.1 units on a U-100 syringe for a 2mcg dose. This vial will last 0 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2 mcg/kg | IV bolus + 0.01 mcg/kg/min infusion |
| Moderate | 2 mcg/kg | IV bolus + 0.01 mcg/kg/min infusion |
| Aggressive | 2 mcg/kg | IV bolus + 0.03 mcg/kg/min infusion |
Nesiritide is discontinued from the US market. This page exists for clinical reference, not practical sourcing guidance. You won't find it through any legitimate supply channel. When it was available, each 1.5 mg vial got reconstituted with 5 mL of diluent pulled from a 250 mL IV bag (D5W, normal saline, or 5% dextrose/0.2% NaCl). That gave 0.32 mg/mL in the vial. The entire contents then went back into the 250 mL bag for a final concentration of roughly 6 mcg/mL. For a 70 kg patient: the bolus is 2 mcg/kg = 140 mcg, which is about 23 mL of the 6 mcg/mL solution, given over 60 seconds. Maintenance runs at 0.01 mcg/kg/min = 0.7 mcg/min = 7 mL/hr on the infusion pump. The thing most residents miss: stopping the infusion doesn't stop the hypotension. Plan for 2+ hours of blood pressure monitoring after you turn it off. And never run it through the same line as heparin or furosemide; it precipitates.
Dosing based on NATRECOR (nesiritide) FDA Prescribing Information (2019) — 7 published references.View all sources →
Cross-check your Nesiritide (Natrecor) reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Nesiritide (Natrecor) is a recombinant BNP that lowers pulmonary pressures within 15 minutes in acute heart failure. FDA-approved in 2001 but discontinued after ASCEND-HF (n=7,141) showed no mortality benefit. Hospital-only IV drug with no approved community use or self-administration potential.
