Exenatide (Byetta / Bydureon) Dosage Calculator

Both Byetta and Bydureon BCise were permanently discontinued in October 2024. No generic is available in the US. If you still have pens from before the discontinuation, check the expiration date and don't use anything past it. Byetta came as pre-filled pens. No reconstitution needed. The 5 mcg pen delivered 60 doses (one month at twice daily); the 10 mcg pen also delivered 60 doses. No bacteriostatic water, no insulin syringes, no mixing. Refrigerate before first use; after that, room temperature up to 30 degrees C for 30 days. Bydureon required reconstituting a microsphere suspension immediately before injection. It came in single-dose kits. The BCise autoinjector simplified this, but neither can be replicated by a compounding pharmacy. The biggest mistake most beginners made was timing. Inject within 60 minutes before the meal, not after. If you took it after eating, nausea got worse and glucose control suffered. Keep the two daily doses at least 6 hours apart. If you're on oral medications like antibiotics or birth control pills, take those at least one hour before your exenatide injection. The gastric emptying delay will slow their absorption otherwise. For anyone currently searching for exenatide: transition to semaglutide or tirzepatide with prescriber guidance.