How many units of Exenatide (Byetta / Bydureon) should I draw?

It depends on your vial size, BAC water, and dose. For a 0.25mg vial with 0mL BAC water, a beginner dose of 5mcg is typically 0 units on a U-100 syringe. Use the calculator above for your exact numbers.

How much BAC water should I add to Exenatide (Byetta / Bydureon)?

The standard amount is 0mL of bacteriostatic water for a 0.25mg vial. More water gives a more dilute solution — easier to measure small doses. Less water means fewer injections per vial. Adjust the BAC water slider in the calculator to see how it changes your syringe units.

How long does a Exenatide (Byetta / Bydureon) vial last?

At a beginner dose of 5mcg 2x daily, a 0.25mg vial lasts about 50 doses. The calculator shows exact doses per vial for your selected tier.

What syringe should I use for Exenatide (Byetta / Bydureon)?

Most people use a U-100 insulin syringe (1mL / 100 units). For very small doses, a U-50 or U-30 syringe gives better precision. The calculator adjusts units automatically for whichever syringe you pick.

Exenatide (Byetta / Bydureon) Dosage Calculator

Weight LossInjectionFDA Approved~2.4 hours half-life

Exenatide is a synthetic version of exendin-4, a 39-amino-acid peptide originally discovered in the saliva of the Gila monster lizard.

First-in-class GLP-1 receptor agonist with extensive long-term safety dataReduces HbA1c by approximately 0.8-1.0% in clinical trialsPromotes weight loss of 2-3 kg over 30 weeksGlucose-dependent insulin secretion minimizes hypoglycemia risk

Vial Size

BAC Water (mL)

Dosing Level

5mcg · 2x Daily

Custom Dose (mcg) — optional

Syringe Type

0.0 units

100 units (1mL)

Concentration

mcg/mL

Draw Volume

< 0.001

Syringe Units

< 0.1

units

Doses / Vial

doses

Summary: Add 0mL BAC water to your 0.25mg vial. Draw to < 0.1 units on a U-100 syringe for a 5mcg dose. This vial will last 0 doses.

Cycle Planner

Cycle Length (weeks)

Price Per Vial ($) — optional

Subcutaneous. Typical beginner frequency: 2x daily.

Exenatide (Byetta / Bydureon) Pharmacokinetics

Pharmacokinetics — Active Dose Over Time

t½ = ~2.4 hours (Byetta IR); ~2 weeks sustained release (Bydureon ER)

After 1 half-life (2h): 50% remainsAfter 2 half-lives (5h): 25% remainsAfter 3 half-lives (7h): 12.5% remains

At a 10mcg dose: 50% = 5mcg remaining after 2h. Recommended frequency: 2x Daily.

Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.

Exenatide (Byetta / Bydureon) Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	5mcg	2x Daily
Moderate	10mcg	2x Daily
Aggressive	2mg	Weekly

Note: First GLP-1 receptor agonist approved by the FDA (2005). Byetta: 5mcg or 10mcg twice daily via pre-filled pen. Bydureon: 2mg once weekly extended-release microsphere suspension. Titrate Byetta from 5mcg to 10mcg after 1 month. Carries a black box warning for medullary thyroid carcinoma risk.

About Exenatide (Byetta / Bydureon)

Exenatide is a synthetic version of exendin-4, a 39-amino-acid peptide originally discovered in the saliva of the Gila monster lizard. It was the first GLP-1 receptor agonist approved for type 2 diabetes (Byetta, FDA approved April 2005). Exenatide shares 53% sequence homology with human GLP-1 but resists degradation by DPP-4 enzyme, giving it a longer duration of action. It enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon, slows gastric emptying, and reduces appetite. Bydureon, an extended-release microsphere formulation approved in 2012, allows once-weekly dosing.

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