What is the recommended Hexarelin dosage?

Hexarelin dosing varies by experience level. Beginners typically start at 100mcg daily, moderate users at 200mcg 2x daily, and aggressive protocols use 300mcg 2x daily.

How do you reconstitute Hexarelin?

Hexarelin typically comes in 2mg or 5mg vials. Add 2mL of bacteriostatic water to the vial. Use our free calculator for exact syringe units based on your desired dose.

What is the half-life of Hexarelin?

The half-life of Hexarelin is ~70 min. This determines how frequently you need to dose for consistent blood levels.

Hexarelin

Growth HormoneInjectionResearchGrade B~70 min half-life

GHRPGrowth HormoneGH SecretagogueGhrelin Receptor AgonistCardioprotectiveCD36 Agonist4 weeks on / 4 weeks off

Benefits

Strongest GH pulse of any GHRP

Potent muscle growth and fat loss

Enhances deep sleep when dosed at night

Cardioprotective properties shown in research

Synergistic with GHRH peptides

Half-Life

~70 min

Route

Injection

Frequency

Daily

Vial Sizes

2mg, 5mg

BAC Water

2mL

Safety Grade

Grade B

Open Hexarelin Dosage Calculator

Calculate exact syringe units for your vial and dose

About Hexarelin

Hexarelin is the most potent growth hormone releasing peptide (GHRP) available, producing the largest GH pulse of any secretagogue. It works by mimicking ghrelin at the pituitary and hypothalamus. However, it also significantly raises cortisol and prolactin — more than GHRP-2 or GHRP-6 — and is prone to desensitization with continuous use. It's best used in short cycles for maximum GH output, stacked with a GHRH for amplified GH output.

Who Should Consider Hexarelin

Adults seeking the most potent GH pulse for short-term body recomposition cycles
Individuals interested in peptide-based cardioprotective support (research context)
Experienced peptide users comfortable managing cortisol and prolactin elevation
Athletes in short recovery-focused phases who can cycle on and off appropriately
Researchers studying GHS-R1a and CD36-mediated cardiac signaling pathways

How Hexarelin Works

Hexarelin is a synthetic hexapeptide (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2) that binds to the growth hormone secretagogue receptor (GHS-R1a) at both the pituitary and hypothalamus, triggering the strongest GH pulse of any GHRP. Unlike more selective GHRPs, hexarelin also activates ACTH/cortisol and prolactin pathways. Independently of GH release, hexarelin binds the CD36 scavenger receptor on cardiomyocytes, producing direct cardioprotective effects including reduced fibrosis, preserved cell shortening during ischemia-reperfusion, and regulation of intracellular calcium.

What to Expect

Days 1-3

Initial GH pulse detectable within 30 minutes of first dose. Mild hunger increase and possible facial flushing. Sleep quality may begin to improve with evening dosing.

Week 1

Consistent GH and IGF-1 elevation. Noticeable appetite increase. Mild water retention and potential tingling or numbness at higher doses.

Weeks 2-3

Recovery benefits become apparent. Fat loss and improved sleep solidify. Cortisol and prolactin effects may be noticeable at aggressive doses.

Week 4

Peak GH response before receptor desensitization sets in. Best body composition changes observed. Transition to off-cycle period recommended.

Weeks 5-8

off-cycle

GHS receptor sensitivity resets over 2-4 weeks. Most body composition gains are retained. GH and IGF-1 gradually return toward baseline.

Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	100mcg	Daily
Moderate	200mcg	2x Daily
Aggressive	300mcg	2x Daily

Note: Most potent GHRP for raw GH release. Raises cortisol and prolactin more than other GHRPs. Desensitization can occur — cycle 4 weeks on, 2-4 weeks off. Best on empty stomach.

How to Inject Hexarelin

Inject subcutaneously on an empty stomach (no food 30 minutes before or after). Best timing is before bed to amplify the natural nocturnal GH pulse, or post-workout. For maximum GH output, stack with a GHRH such as CJC-1295 No DAC injected at the same time.

Cycling Protocol

On Period

4 weeks

Off Period

4 weeks

Hexarelin desensitizes GHS receptors with continuous use. Cycle 4 weeks on, 2-4 weeks off to maintain GH responsiveness. Some protocols use 5 days on, 2 days off within each on-cycle week.

Pharmacokinetics

Half-Life

1.17h

Bioavailability

SC: estimated 60-70%; Oral: ~0.3%

Tmax

~0.5 hours (GH peak at ~30 min)

Data Confidence

moderate

Source: Human plasma t½ ~55-70 min (Ghigo et al. 1994, PMID 8126144; rat IV t½ 75.9 min, PMID 10611139)

Pharmacokinetics — Active Dose Over Time

Loading the interactive decay curve.

Side Effects

Cortisol and prolactin elevation (higher than other GHRPs). Desensitization with continuous use. Water retention. Intense hunger. Tingling and numbness.

Contraindications

Active malignancy or history of cancer (GH and IGF-1 elevation may promote tumor growth)
Pregnancy or breastfeeding (insufficient safety data in humans)
Severe cardiac arrhythmias (requires cardiac monitoring despite cardioprotective research)
Uncontrolled diabetes or significant insulin resistance (GH elevation impairs glucose tolerance)
Known hypersensitivity to hexarelin or related GH secretagogue peptides
Active pituitary tumors or intracranial hypertension

Drug Interactions

Exogenous growth hormone (HGH) — concurrent use risks supraphysiological GH levels and amplified side effects
Glucocorticoids (prednisone, dexamethasone) — may blunt GH release and reduce hexarelin efficacy
Insulin — combined GH elevation can worsen glucose tolerance; monitor blood sugar closely
Somatostatin analogs (octreotide) — directly oppose GH release and will negate hexarelin effects
Testosterone and estrogen compounds — may potentiate GH-releasing effects of hexarelin, requiring dose adjustment