What is the recommended Glutathione dosage?

Glutathione dosing varies by experience level. Beginners typically start at 200000mcg 2x/week, moderate users at 400000mcg 2x/week, and aggressive protocols use 600000mcg 3x/week.

How do you reconstitute Glutathione?

Glutathione typically comes in 1500mg vials. Add 3mL of bacteriostatic water to the vial. Use our free calculator for exact syringe units based on your desired dose.

What is the half-life of Glutathione?

The half-life of Glutathione is ~10 min (plasma); 2-3 hours (intracellular). This determines how frequently you need to dose for consistent blood levels.

Glutathione

Anti-AgingInjectionResearchGrade A~10 min (plasma); 2-3 hours (intracellular) half-life

AntioxidantDetoxificationSkin BrighteningLiver SupportAnti-Aging12 weeks on / 2 weeks off

Benefits

Master antioxidant — neutralizes free radicals

Detoxifies the liver

Brightens and evens skin tone

100% bioavailability via injection (vs 10% oral)

Supports immune function

Half-Life

~10 min

Route

Injection

Frequency

2x/week

Vial Sizes

1500mg

BAC Water

3mL

Safety Grade

Grade A

Open Glutathione Dosage Calculator

Calculate exact syringe units for your vial and dose

About Glutathione

Glutathione is the body's master antioxidant — a tripeptide produced in every cell. It neutralizes free radicals, detoxifies the liver, supports immune function, and brightens skin. Oral supplements have poor bioavailability (~10%), but injectable glutathione delivers 100% directly to the bloodstream. It's essential for Phase II liver detoxification and protects mitochondria from oxidative damage.

Who Should Consider Glutathione

Adults seeking antioxidant and detoxification support
Individuals with elevated oxidative stress from chronic illness or environmental exposure
Those pursuing skin brightening or evening of skin tone
Patients undergoing liver-supportive therapy (under medical supervision)
Athletes recovering from high-intensity training with elevated ROS production

How Glutathione Works

Glutathione (GSH) is a tripeptide of glutamate, cysteine, and glycine that functions as the primary intracellular antioxidant. It donates electrons via its sulfhydryl group to neutralize reactive oxygen species (ROS) and free radicals, becoming oxidized glutathione (GSSG) in the process. The enzyme glutathione reductase regenerates GSH from GSSG using NADPH. GSH also serves as a cofactor for glutathione peroxidase and glutathione S-transferase, which are central to Phase II liver detoxification. In melanocytes, GSH inhibits tyrosinase activity and shifts melanin synthesis from dark eumelanin toward lighter phaeomelanin, producing skin-brightening effects.

What to Expect

Week 1

Most users notice increased energy and reduced brain fog within the first few sessions. IV administration shows effects faster than IM or SubQ. No visible skin changes yet.

Weeks 2-4

Improved recovery from exercise, reduced hangover severity, and general well-being reported. Skin may begin to appear slightly brighter or more even-toned at higher doses.

Weeks 4-8

Noticeable skin brightening in many users, especially at doses of 400-600mg 2-3x/week. Nail and hair quality may improve. Liver enzyme panels often show improvement if previously elevated.

Weeks 8-12+

Peak skin-lightening and antioxidant benefits with consistent use. Continued immune and detoxification support. Many users maintain a lower-frequency schedule for upkeep.

Dosing Protocol

Level	Dose / Injection	Frequency
Beginner	200mg	2x/week
Moderate	400mg	2x/week
Aggressive	600mg	3x/week

Note: Master antioxidant. Doses shown in mcg: 200,000mcg = 200mg, 400,000mcg = 400mg, 600,000mcg = 600mg. IV or IM provides 100% bioavailability vs ~10% oral absorption. Skin brightening at higher doses.

How to Inject Glutathione

IV push is most common in clinical settings (over 5-10 minutes). For IM or SubQ home use, inject into abdominal fat or deltoid. Rotate injection sites. GSH is light-sensitive — store vials away from direct light. Can be combined with vitamin C IV drips for synergistic antioxidant effect.

Cycling Protocol

On Period

12 weeks

Off Period

2 weeks

No desensitization documented, but periodic breaks are commonly recommended. Some users maintain indefinitely at lower frequency (1x/week) without cycling off.

Pharmacokinetics

Half-Life

10min

Bioavailability

IV: 100%; IM/SubQ: near 100% (parenteral bypass of first-pass metabolism); Oral: ~10% due to GI degradation

Tmax

IV: immediate; IM/SubQ: 30-60 minutes (estimated)

Data Confidence

moderate

Source: IV GSH is rapidly oxidized to GSSG with a plasma t½ of ~10 minutes; Aebi et al. 1991 PMID 1907548. Intracellular t½ is longer at 2-3 hours.

Pharmacokinetics — Active Dose Over Time

Loading the interactive decay curve.

Side Effects

Very well-tolerated. Injection site reactions. Rare: zinc depletion with very high chronic doses.

Contraindications

Pregnancy or breastfeeding (insufficient safety data for injectable GSH)
Known allergy to glutathione or any component of the formulation
Active asthma (inhaled GSH may trigger bronchospasm; use injectable forms with caution)
Organ transplant recipients on immunosuppressive therapy (GSH may modulate immune response)

Drug Interactions

Cisplatin and other platinum-based chemotherapeutics — GSH may reduce nephrotoxicity but could theoretically affect drug efficacy; use only under oncologist guidance
Acetaminophen — GSH is depleted during acetaminophen metabolism; high acetaminophen use increases GSH demand
Nitroglycerin — concurrent GSH administration may potentiate hypotensive effects
Cyclophosphamide — GSH has shown protective effects against urotoxicity in animal models; clinical relevance under investigation
Immunosuppressants (tacrolimus, cyclosporine) — GSH immune-modulating properties may interfere with immunosuppression