Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202610 Citations
Ziconotide (Prialt)25 residuesCKGKGAKCSRLMYDCCTGSCRSGKCEach bubble = one amino acid. Size = residue mass. Color = chemical class.Ziconotide (Prialt) is an FDA-approved cone snail venom peptide for severe refractory pain. Delivered by intrathecal pump, it blocks Cav2.2 calcium channels without opioid tolerance or respiratory depression. Black Box Warning for psychiatric and cognitive side effects including confusion and hallucinations.
2.4mcg · Daily
Summary: Add 0mL BAC water to your 1mg vial. Draw to < 0.1 units on a U-100 syringe for a 2.4mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2.4mcg | Daily |
| Moderate | 9.6mcg | Daily |
| Aggressive | 19.2mcg | Daily |
Ziconotide ships as a pre-filled solution, not a lyophilized powder. No reconstitution with bacteriostatic water is needed. The two concentrations are 25 mcg/mL and 100 mcg/mL. Delivery math for the 25 mcg/mL formulation in a 20 mL vial: 500 mcg total per vial. At a maintenance dose of 5 mcg/day, that is a 100-day supply per pump refill. The 100 mcg/mL concentration must be diluted with preservative-free normal saline (not bacteriostatic water) when used in external pumps. The FDA label says you can start at 2.4 mcg/day. Most pain specialists don't anymore. The 2024 PACC consensus guidelines recommend 0.5 to 1.0 mcg/day with increases no larger than 0.5 mcg/day per week. That slower ramp cuts psychiatric and cognitive side effects dramatically compared to the FDA-label titration speed. Your pump refill schedule depends on concentration, flow rate, and reservoir size. Typical intervals run every 1 to 3 months. Every refill visit should include cognitive screening, psychiatric assessment, orthostatic blood pressure, and CK levels.
Dosing based on Prialt (ziconotide) intrathecal infusion FDA Prescribing Information (2011) — 15 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Ziconotide (Prialt) is an FDA-approved cone snail venom peptide for severe refractory pain. Delivered by intrathecal pump, it blocks Cav2.2 calcium channels without opioid tolerance or respiratory depression. Black Box Warning for psychiatric and cognitive side effects including confusion and hallucinations.
