Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202610 Citations
Ziconotide (Prialt)25 residuesCKGKGAKCSRLMYDCCTGSCRSGKCEach bubble = one amino acid. Size = residue mass. Color = chemical class.Beginner, moderate, and aggressive dosing amounts with timing. Free, no signup.
Intrathecal (continuous infusion via implanted or external pump)
Ziconotide (Prialt) has no standard bacteriostatic water volume on file, so there are no syringe units to calculate here. Dosing runs 2.4mcg to 19.2mcg per administration, daily. A 1mg supply covers about 416 doses at the beginner tier.
If your product does arrive as a powder, use the universal reconstitution calculator and enter your own vial size and water volume.
Ziconotide (Prialt) is an FDA-approved cone snail venom peptide for severe refractory pain. Delivered by intrathecal pump, it blocks Cav2.2 calcium channels without opioid tolerance or respiratory depression. Black Box Warning for psychiatric and cognitive side effects including confusion and hallucinations.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2.4mcg | Daily |
| Moderate | 9.6mcg | Daily |
| Aggressive | 19.2mcg | Daily |
Ziconotide ships as a pre-filled solution, not a lyophilized powder. No reconstitution with bacteriostatic water is needed. The two concentrations are 25 mcg/mL and 100 mcg/mL. Delivery math for the 25 mcg/mL formulation in a 20 mL vial: 500 mcg total per vial. At a maintenance dose of 5 mcg/day, that is a 100-day supply per pump refill. The 100 mcg/mL concentration must be diluted with preservative-free normal saline (not bacteriostatic water) when used in external pumps. The FDA label says you can start at 2.4 mcg/day. Most pain specialists don't anymore. The 2024 PACC consensus guidelines recommend 0.5 to 1.0 mcg/day with increases no larger than 0.5 mcg/day per week. That slower ramp cuts psychiatric and cognitive side effects dramatically compared to the FDA-label titration speed. Your pump refill schedule depends on concentration, flow rate, and reservoir size. Typical intervals run every 1 to 3 months. Every refill visit should include cognitive screening, psychiatric assessment, orthostatic blood pressure, and CK levels.
Dosing based on Prialt (ziconotide) intrathecal infusion FDA Prescribing Information (2011) — 15 published references.View all sources →
Cross-check your Ziconotide (Prialt) reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
