Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20267 Citations
Syn-Ake3 residues (approx.)APKEach bubble = one amino acid. Size = residue mass. Color = chemical class.Uses closest standard amino acids for non-standard residues.Beginner, moderate, and aggressive dosing amounts with timing. Free, no signup.
Topical
Syn-Ake has no standard bacteriostatic water volume on file, so there are no syringe units to calculate here. Dosing runs 2mg to 6mg per administration, daily. A 5mg supply covers about 2 doses at the beginner tier.
If your product does arrive as a powder, use the universal reconstitution calculator and enter your own vial size and water volume.
Syn-Ake is a synthetic tripeptide that blocks postsynaptic acetylcholine receptors to relax facial muscles topically. Manufacturer data shows 52% wrinkle reduction at 28 days, though no independent RCT of the isolated compound exists yet. Often stacked with SNAP-8 for dual-mechanism coverage.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2mg | Daily |
| Moderate | 4mg | 2x Daily |
| Aggressive | 6mg | 2x Daily |
Syn-Ake is a topical peptide. No reconstitution, no bacteriostatic water, no syringes. You're working with serums and creams, not vials. The most common mistake: buying a product that says "contains Syn-Ake" without listing the actual percentage. Below 3%, efficacy drops off. The manufacturer's clinical data used 4%. Garden of Wisdom sells a verified 7% serum ($28 to $87 depending on size) that's the go-to reference product. For DIY formulators working with raw powder (CAS 823202-99-9, approximately $210 per 200 mg from Cenexal Labs or Peptide.shop): dissolve in a hyaluronic acid serum base. 4 mg per 100 mg of final product gives you 4% w/w. That 200 mg supply makes roughly 5 g of 4% serum, enough for about a month of twice-daily facial application. Apply to clean, dry skin. Not damp. Dampness changes absorption kinetics. Wait two to three minutes before layering moisturizer or SPF. Don't apply within 48 hours of a chemical peel. Store finished serums at 2 to 8 degrees Celsius and use within 6 months of opening.
Dosing based on Cosmeceutical industry standard concentrations — 9 published references.View all sources →
Cross-check your Syn-Ake reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
