Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20267 Citations
Syn-Ake3 residues (approx.)APKEach bubble = one amino acid. Size = residue mass. Color = chemical class.Uses closest standard amino acids for non-standard residues.Syn-Ake is a synthetic tripeptide that blocks postsynaptic acetylcholine receptors to relax facial muscles topically. Manufacturer data shows 52% wrinkle reduction at 28 days, though no independent RCT of the isolated compound exists yet. Often stacked with SNAP-8 for dual-mechanism coverage.
2mcg · Daily
Summary: Add 0mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 2mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2mg | Daily |
| Moderate | 4mg | 2x Daily |
| Aggressive | 6mg | 2x Daily |
Syn-Ake is a topical peptide. No reconstitution, no bacteriostatic water, no syringes. You're working with serums and creams, not vials. The most common mistake: buying a product that says "contains Syn-Ake" without listing the actual percentage. Below 3%, efficacy drops off. The manufacturer's clinical data used 4%. Garden of Wisdom sells a verified 7% serum ($28 to $87 depending on size) that's the go-to reference product. For DIY formulators working with raw powder (CAS 823202-99-9, approximately $210 per 200 mg from Cenexal Labs or Peptide.shop): dissolve in a hyaluronic acid serum base. 4 mg per 100 mg of final product gives you 4% w/w. That 200 mg supply makes roughly 5 g of 4% serum, enough for about a month of twice-daily facial application. Apply to clean, dry skin. Not damp. Dampness changes absorption kinetics. Wait two to three minutes before layering moisturizer or SPF. Don't apply within 48 hours of a chemical peel. Store finished serums at 2 to 8 degrees Celsius and use within 6 months of opening.
Dosing based on Cosmeceutical industry standard concentrations — 9 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Syn-Ake is a synthetic tripeptide that blocks postsynaptic acetylcholine receptors to relax facial muscles topically. Manufacturer data shows 52% wrinkle reduction at 28 days, though no independent RCT of the isolated compound exists yet. Often stacked with SNAP-8 for dual-mechanism coverage.
