Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 202612 Citations
Plecanatide (Trulance)16 residuesNDSCEICAFAACTGCLEach bubble = one amino acid. Size = residue mass. Color = chemical class.Plecanatide (Trulance) is an FDA-approved oral GC-C agonist for CIC and IBS-C. Same class as linaclotide but with far lower diarrhea rates (5% vs 19%). One fixed 3 mg tablet daily; no titration required. Approved for adults 18 and older.
3mcg · Daily
Summary: Add 0mL BAC water to your 3mg vial. Draw to < 0.1 units on a U-100 syringe for a 3mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 3mg | Daily |
| Moderate | 3mg | Daily |
| Aggressive | 3mg | Daily |
Trulance is an oral tablet. No vials, no bacteriostatic water, no syringes. That alone sets it apart from most peptides on this site. The dose is 3 mg once daily by mouth. Take it whenever is convenient; there's no food restriction and no timing requirement. Swallow the tablet whole with water. If swallowing pills is an issue, you can crush the tablet and mix it with one teaspoon of room-temperature applesauce. Swallow immediately without chewing. Don't store the mixture. For tube feeding: crush the tablet, dissolve in 30 mL of room-temperature water, draw into a syringe, and administer within 10 minutes. Flush the tube with 30 mL water afterward. One thing beginners often miss: give it a real trial period. The strict durable responder definition requires weeks of consistent improvement. Evaluating at day 3 or 4 misses the point. Allow 2 to 4 weeks before deciding if it's working. If you're switching from Linzess because of diarrhea (the most common reason people switch), the diarrhea improvement is typically obvious within the first week. Store tablets in the original bottle with the desiccant cap. Moisture is the enemy.
Dosing based on Trulance (plecanatide) FDA Prescribing Information (2018) — 15 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Plecanatide (Trulance) is an FDA-approved oral GC-C agonist for CIC and IBS-C. Same class as linaclotide but with far lower diarrhea rates (5% vs 19%). One fixed 3 mg tablet daily; no titration required. Approved for adults 18 and older.
