Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20268 Citations
MIF-1 (Pro-Leu-Gly-NH2)3 residuesPLGEach bubble = one amino acid. Size = residue mass. Color = chemical class.MIF-1 (melanostatin, PLG) is an endogenous tripeptide that allosterically modulates dopamine D2 and D4 receptors. One small double-blind trial showed an 89% antidepressant responder rate, but no replication exists. Used in short 5 to 7 day subcutaneous courses for anhedonia.
5mcg · Daily
Summary: Add 2mL BAC water to your 10mg vial. Draw to 0.1 units on a U-100 syringe for a 5mcg dose. This vial will last 2000 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 5mg | Daily |
| Moderate | 10mg | Daily |
| Aggressive | 10mg | Daily |
Reconstitution math matters here because the vial sizes and standard dose create specific syringe calculations. For a 10 mg vial, add 1 mL bacteriostatic water to get 10 mg/mL. Your full 10 mg dose is the entire 1 mL syringe (100 units on an insulin syringe). A 5 mg starter dose is 50 units. Don't use the calculator default of 2 mL; that gives you 5 mg/mL and you'll underdose if you're not recalculating. For a 50 mg vial, add 2 mL bacteriostatic water for 25 mg/mL. Each 10 mg dose is 0.4 mL (40 units). That gets you five 10 mg doses per vial, which covers one full course. The non-obvious thing most beginners miss: MIF-1 is NOT the same molecule as MIF (macrophage migration inhibitory factor). When reading forums or ordering, confirm CAS 2002-44-0 and the sequence Pro-Leu-Gly-NH2. The naming collision causes real confusion in search results and vendor listings. Sourcing is the biggest practical problem. Only 1 to 2 verified US vendors carry it. Order enough for 2 to 3 cycles before starting; supply disruptions have left users stranded mid-protocol.
Dosing based on Depression RCTs: 10 mg SC daily (Ehrensing & Kastin 1986; PMID 3536184) — 14 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
MIF-1 (melanostatin, PLG) is an endogenous tripeptide that allosterically modulates dopamine D2 and D4 receptors. One small double-blind trial showed an 89% antidepressant responder rate, but no replication exists. Used in short 5 to 7 day subcutaneous courses for anhedonia.
