Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20269 Citations
Matrixyl 30007 residues (approx.)GHKGQPREach bubble = one amino acid. Size = residue mass. Color = chemical class.Uses closest standard amino acids for non-standard residues.Matrixyl 3000 pairs two matrikine peptides for dual-action anti-aging: collagen synthesis plus anti-inflammatory protection. Sederma's clinical trial showed 45% wrinkle reduction at 2 months. Topical, well-tolerated, compatible with retinoids and vitamin C. Community-favorite upgrade over original Matrixyl. Works in both AM and PM routines.
2mcg · Daily
Summary: Add 0mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 2mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 2mg | Daily |
| Moderate | 5mg | 2x Daily |
| Aggressive | 10mg | 2x Daily |
This one is topical, so no vials, no syringes, no bacteriostatic water. You're shopping for a serum, not a lyophilized powder. The number that matters is complex concentration. Sederma's clinical data used 3% Matrixyl 3000 complex. Products that list "Matrixyl 3000" without disclosing the percentage probably contain too little to match clinical results. Look for palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 both appearing in the top 10 INCI ingredients; if they're near the bottom, the concentration is cosmetic-grade marketing rather than clinical-grade dosing. The Ordinary's Matrixyl 10% + HA lists 10% combined Matrixyl 3000 and Matrixyl Synthe'6 at about $15 for 30ml. That's transparent labeling. Paula's Choice Peptide Booster runs $58 for 20ml. Raw Sederma complex costs $80 to $200 per gram for DIY formulators. Apply to clean, dry skin. Wait 2 to 3 minutes before layering other products. If you're using GHK-Cu in the same routine, apply that first (lower molecular weight, faster absorption). Retinoid and Matrixyl 3000 work fine together but if your skin is sensitive, split them: Matrixyl AM, retinoid PM.
Dosing based on Cosmeceutical industry standard concentrations — 10 published references.View all sources →
Cross-check your Matrixyl 3000 reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Matrixyl 3000 pairs two matrikine peptides for dual-action anti-aging: collagen synthesis plus anti-inflammatory protection. Sederma's clinical trial showed 45% wrinkle reduction at 2 months. Topical, well-tolerated, compatible with retinoids and vitamin C. Community-favorite upgrade over original Matrixyl. Works in both AM and PM routines.
