Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20265 Citations
Linaclotide (Linzess)14 residuesCCEYCCNPACTGCYEach bubble = one amino acid. Size = residue mass. Color = chemical class.Linaclotide (Linzess) is one of the few peptides you swallow rather than inject. FDA-approved for IBS-C and chronic constipation, it works locally inside the gut to increase fluid secretion and reduce visceral pain. Diarrhea at higher doses is the trade-off; community users often find lower doses equally effective.
72mcg · Daily
Summary: Add 0mL BAC water to your 0.072mg vial. Draw to < 0.1 units on a U-100 syringe for a 72mcg dose. This vial will last 0 doses.
View side effects and safety warnings →
| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 72mcg | Daily |
| Moderate | 145mcg | Daily |
| Aggressive | 290mcg | Daily |
No vials, no syringes, no bacteriostatic water. Linaclotide is an oral capsule. Swallow it whole on an empty stomach, at least 30 minutes before eating. Set an alarm if that helps; the fasting window matters. The 72 mcg dose covers CIC (adults) and pediatric functional constipation (ages 6 to 17). The 145 mcg dose is for adult CIC and pediatric IBS-C (ages 7 to 17). The 290 mcg dose targets adult IBS-C specifically. If you can't swallow capsules, open them and sprinkle the beads onto room-temperature applesauce. Swallow immediately without chewing. They also work through NG or gastrostomy tubes mixed with water. Don't use hot food, don't chew the beads, don't store the mixture. Store at room temperature (20 to 25 degrees C). No refrigeration needed. One thing that catches people off guard: symptoms come back within about a week of stopping. This isn't dependency; it's just how local-acting drugs work. GC-C receptors don't desensitize, but they also don't stay activated once you stop providing the agonist.
Dosing based on Linzess (linaclotide) FDA Prescribing Information (2025) — 7 published references.View all sources →
Cross-check your Linaclotide (Linzess) reconstitution math with AI
Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Linaclotide (Linzess) is one of the few peptides you swallow rather than inject. FDA-approved for IBS-C and chronic constipation, it works locally inside the gut to increase fluid secretion and reduce visceral pain. Diarrhea at higher doses is the trade-off; community users often find lower doses equally effective.
