Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20268 Citations
Leuprolide (Lupron)9 residuesHWSYGLRPGEach bubble = one amino acid. Size = residue mass. Color = chemical class.Leuprolide (Lupron) is an FDA-approved GnRH agonist prescribed for prostate cancer, endometriosis, uterine fibroids, and precocious puberty. Depot formulations cover monthly to six-month dosing. The initial hormone flare requires careful management, and bone density monitoring is standard during therapy. Over 4,160 PubMed publications support its clinical profile.
1mcg · Daily
Summary: Add 0mL BAC water to your 5mg vial. Draw to < 0.1 units on a U-100 syringe for a 1mcg dose. This vial will last 0 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 1mg | Daily |
| Moderate | 7.5mg | Monthly |
| Aggressive | 22.5mg | Every 3 months |
Leuprolide comes in very different formulations, and mixing them up is the most common beginner mistake. The daily subcutaneous injection is 1 mg/day from a 5 mg/mL vial (0.2 mL per dose, which is 20 units on a U-100 insulin syringe). That formulation needs refrigeration at 2 to 8 degrees C. The depot kits are a completely different product. Lupron Depot comes as lyophilized microspheres that you reconstitute with the included diluent. Swirl gently; never shake. The suspension should look uniform and milky white. Inject it immediately after mixing. You can't store reconstituted depot. Depot kits store at room temperature (15 to 30 degrees C). Don't refrigerate them. For prostate cancer patients: the bicalutamide pre-load before your first injection isn't optional if you have bone mets or high tumor burden. Start it seven days before the first depot shot. For endometriosis patients: norethindrone 5 mg/day add-back from day one reduces hot flashes and protects bone density. Most community members and current guidelines strongly recommend it.
Dosing based on Lupron Depot (leuprolide acetate) FDA Prescribing Information (2012) — 12 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
Leuprolide (Lupron) is an FDA-approved GnRH agonist prescribed for prostate cancer, endometriosis, uterine fibroids, and precocious puberty. Depot formulations cover monthly to six-month dosing. The initial hormone flare requires careful management, and bone density monitoring is standard during therapy. Over 4,160 PubMed publications support its clinical profile.
