Icatibant (Firazyr) Dosage Calculator

Icatibant arrives in a pre-filled syringe. No reconstitution math needed here, which is unusual for this platform. The syringe contains 30 mg in 3 mL (10 mg/mL concentration) with a 25-gauge, half-inch needle already attached. You're injecting the full syringe contents every time. Store below 25 degrees Celsius. Don't freeze it. A frozen syringe is a discarded syringe. Keep it in the original packaging away from light. When traveling, bring at least 2 to 3 syringes; one may not be enough for a severe or recurrent attack. The non-obvious thing most beginners miss: speed of injection matters. Thirty seconds minimum for the full 3 mL. Pushing faster makes the site reaction much worse. Some patients use a timer on their phone. For laryngeal attacks, don't wait to see if the drug works before calling emergency services. Inject AND call simultaneously. Airway compromise can progress faster than icatibant's onset of action. One more practical note: keep your attack frequency log current. If you're reaching for icatibant more than once a month, that's a signal to discuss prophylaxis options (lanadelumab, berotralstat, C1-INH replacement) with your HAE specialist.