Not medical advice. Talk to your provider before using any peptide.
Full disclaimerPeptide Schedule Research TeamReviewed Apr 20265 Citations
FOXO4-DRI17 residuesLTLRKEPASEIAQSILEEach bubble = one amino acid. Size = residue mass. Color = chemical class.FOXO4-DRI is a D-retro-inverso senolytic peptide that selectively kills senescent cells by freeing p53 from nuclear sequestration. Mouse data from Baar et al. (Cell, 2017) showed fitness restoration and kidney function recovery. Zero human trials exist. Community protocols use pulsed 3-dose courses with months of rest between.
1mg · EOD x3 doses (6-day pulse)
Summary: Add 2mL BAC water to your 5mg vial. Draw to 40.0 units on a U-100 syringe for a 1mg dose. This vial will last 5 doses.
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| Level | Dose / Injection | Frequency |
|---|---|---|
| Beginner | 1mg | EOD x3 doses (6-day pulse) |
| Moderate | 3mg | EOD x3 doses (6-day pulse) |
| Aggressive | 25mg | EOD x3 doses (6-day pulse) |
The big practical issue with FOXO4-DRI is dosing unit confusion. All community protocols use milligrams (mg). Vendor vials come in 5 mg and 10 mg sizes. The site's dosing tiers list 500 mcg and 1000 mcg, which are 0.5 mg and 1 mg. Triple-check your math before injecting because a 1000x error between mcg and mg is a real risk that has been flagged in community discussions. Reconstitution math for a 10 mg vial: add 2 mL bacteriostatic water to get a concentration of 5 mg/mL. For a 1 mg dose, that's 0.2 mL, which reads as 20 IU on a U-100 insulin syringe. For 3 mg, you're drawing 0.6 mL (60 IU). At the full allometric dose of 25 mg, you need multiple vials and a standard syringe instead of an insulin syringe. For a 5 mg vial with 2 mL bacteriostatic water: concentration is 2.5 mg/mL. A 1 mg dose is 0.4 mL (40 IU). A 0.5 mg dose is 0.2 mL (20 IU). Store reconstituted vials at 2 to 8 degrees Celsius. Use within 7 to 14 days. Lyophilized powder keeps at minus 20 degrees Celsius long-term. Don't shake during reconstitution; swirl gently. Warm the solution to body temperature before injection to reduce nodule risk.
Dosing based on Dose extrapolated from mouse senolytic studies (Baar et al., Cell 2017) using allometric scaling — 7 published references.View all sources →
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Pricing updated 2026-04-09
Prices are estimates and vary by source, location, and prescription status.Full pricing breakdown →
Disclaimer: This curve is a simplified first-order exponential decay model. Actual pharmacokinetics vary based on injection site, individual metabolism, body composition, and other factors. Half-life values are approximate and based on available preclinical and clinical literature. Many research peptides lack formal human pharmacokinetic studies. This is for educational purposes only — not medical advice.
FOXO4-DRI is a D-retro-inverso senolytic peptide that selectively kills senescent cells by freeing p53 from nuclear sequestration. Mouse data from Baar et al. (Cell, 2017) showed fitness restoration and kidney function recovery. Zero human trials exist. Community protocols use pulsed 3-dose courses with months of rest between.
